Academic Journal
Integrating Molecular Networking and 1 H NMR To Target the Isolation of Chrysogeamides from a Library of Marine-Derived Penicillium Fungi
| العنوان: | Integrating Molecular Networking and 1 H NMR To Target the Isolation of Chrysogeamides from a Library of Marine-Derived Penicillium Fungi |
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| المؤلفون: | Hou, Xue-Mei, Li, Yue-Ying, Shi, Yun-Wei, Fang, Yao-Wei, Chao, Rong, Gu, Yu-Cheng, Wang, Chang-Yun, Shao, Chang-Lun |
| بيانات النشر: | ACS |
| سنة النشر: | 2019 |
| المجموعة: | OceanRep (GEOMAR Helmholtz Centre für Ocean Research Kiel) |
| الوصف: | A challenging problem in natural product discovery is to rapidly dereplicate known compounds and expose novel ones from complicated components. Herein, integrating the LC-MS/MS-dependent molecular networking and 1H NMR techniques efficiently and successfully enabled the targeted identification of seven new cyclohexadepsipeptides, chrysogeamides A–G (1–7), from the coral-derived fungus Penicillium chrysogenum (CHNSCLM-0003) which was targeted from a library of marine-derived Penicillium fungi. Compound 4 features a rare 3-hydroxy-4-methylhexanoic acid (HMHA) moiety which was first discovered from marine-derived organisms. Interestingly, isotope-labeling feeding experiments confirmed that 13C1-l-Leu was transformed into 13C1-d-Leu moiety, indicating that d-Leu could be isomerized from l-Leu. Compounds 1 and 2 obviously promoted angiogenesis in zebrafish at 1.0 μg/mL with nontoxic to embryonic zebrafish at 100 μg/mL. Combining molecular networking with 1H NMR as a discovery tool will be implemented as a systematic strategy, not only for known compounds dereplication but also for untapped reservoir discovery. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://oceanrep.geomar.de/id/eprint/49408/1/Hou.pdf; Hou, X. M., Li, Y. Y., Shi, Y. W., Fang, Y. W., Chao, R., Gu, Y. C., Wang, C. Y. and Shao, C. L. (2019) Integrating Molecular Networking and 1 H NMR To Target the Isolation of Chrysogeamides from a Library of Marine-Derived Penicillium Fungi . The Journal of Organic Chemistry, 84 (3). pp. 1228-1237. DOI 10.1021/acs.joc.8b02614 . |
| DOI: | 10.1021/acs.joc.8b02614 |
| الاتاحة: | https://oceanrep.geomar.de/id/eprint/49408/ https://oceanrep.geomar.de/id/eprint/49408/1/Hou.pdf https://doi.org/10.1021/acs.joc.8b02614 |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.D94FDAC7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.joc.8b02614 |
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