Academic Journal
EFFECTS OF VINBLASTINE ON NORADRENERGIC AXONS
| العنوان: | EFFECTS OF VINBLASTINE ON NORADRENERGIC AXONS |
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| المؤلفون: | HANBAUER, I., JACOBOWITZ, D.M., KOPIN, I.J. |
| المصدر: | British Journal of Pharmacology ; volume 50, issue 2, page 219-225 ; ISSN 0007-1188 1476-5381 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1974 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The effects of vinblastine and 6‐hydroxydopamine (6‐OHDA) on various parameters of adrenergic neurone functions in the rat were examined and compared. During the first 12 h after injection of vinblastine, although the concentration of cardiac noradrenaline was unaltered, the turnover rate of the catecholamine in the heart was reduced to 40 ng g −1 h −1 compared to a rate of 66 ng g −1 h −1 in the hearts of animals treated with 0.9% w/v NaCl solution. The uptake of noradrenaline by rat atria in vitro was inhibited by vinblastine (2.5 × 10 −4 m ) or 6‐OHDA (5 × 10 −5 m ), but only the inhibitory effect of vinblastine was readily reversible. The in vitro uptake of noradrenaline by atria of vinblastine‐ or 6‐OHDA‐treated rats was found to be impaired two days after injection of the drugs. After 14 days, however, the noradrenaline uptake was 71% of control values after vinblastine and 91% after 6‐OHDA. In addition to intensely fluorescent nerve trunks in epicardial connective tissue septa, a decrease in the number of fluorescent adrenergic terminals in the atria and ventricles could be observed two days after vinblastine injection. It is suggested that intravenous vinblastine treatment, like 6‐OHDA, results in the destruction of adrenergic nerve terminals. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1476-5381.1974.tb08564.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1476-5381.1974.tb08564.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.1974.tb08564.x https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1974.tb08564.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.D92FEDDF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1476-5381.1974.tb08564.x |
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