Academic Journal
Improvement in serum lipids and liver morphology after supplementation of the diet with fish oil is more evident under regular feeding conditions than under high-fat or mixed diets in rats
| العنوان: | Improvement in serum lipids and liver morphology after supplementation of the diet with fish oil is more evident under regular feeding conditions than under high-fat or mixed diets in rats |
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| المؤلفون: | Silvia Godea (Lupei), Diana Ciubotariu, Mihai Danciu, Raoul Vasile Lupușoru, Cristina Mihaela Ghiciuc, Irina Cernescu, Nicolae Gheţu, Mihai Lupei, Cătălina Elena Lupușoru |
| المصدر: | Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-18 (2020) |
| بيانات النشر: | BMC |
| سنة النشر: | 2020 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | N-3 PUFA, Atherogenesis, Steatosis, Fish oil, Cholesterol, Triglycerides, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Background Dietary n− 3 polyunsaturated fatty acids (PUFAs) have a role in preventing cardiovascular and hepatic diseases. However, their effects might differ significantly depending on individual dietary patterns. The aim of the present study was to evaluate the effects of dietary supplementation with ω-3 fatty acids (FA), administered in different schedules, on hepatic and aortic histological structure, lipid profile, and body weight (BW) in male Wistar rats under standard (SD), high-fat diet (HFD) and mixed feeding conditions. Methods PUFA treatment consisted of the administration of 50 mg/kg fish oil (FO) daily by oral gavage. HFD was obtained by adding a suspension of 4% cholesterol, thiouracil and cholic acid to the animals’ drinking water. The rats were maintained on the diets for 6 weeks, and different schedules of PUFA administration were used. At 14, 28, and 42 days, the morphology of liver and aortic samples and the levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), and triglycerides (TG) were assessed. Results The HFD groups exhibited significant hyperlipidemia and aortic inflammation, with progression to atherogenesis after 6 weeks. Administration of PUFAs slightly attenuated the aortic changes in these groups and reduced the liver’s tendency to steatosis. FO-induced metabolic improvement was more evident in SD than in HFD rats. For instance, after the first 2 weeks, SD animals that received PUFAs had significantly increased HDL levels vs. controls (62.375 ± 4.10 vs. 52.625 ± 8.38 mg/dL, P < 0.05), but HFD rats did not, and decreased TG levels were observed exclusively in the SD rats (57.6 ± 4.09 vs. 66 ± 4.69 mg/dL, P < 0.05). After 6 weeks of n− 3 PUFA administration, LDL was significantly lower in the SD rats than in controls (13.67 ± 4.13 vs. 30.83 ± 2.86 mg/dL, P < 0.001), but the decrease in the HFD rats, although significant (49.17 ± 5.85 mg/dL vs. 57.17 ± 4.96 g/dL, P < 0.05), was not as marked. In the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1476-511X |
| Relation: | http://link.springer.com/article/10.1186/s12944-020-01339-y; https://doaj.org/toc/1476-511X; https://doaj.org/article/c0ac868fe1a246bf9aaa759322cdb44c |
| DOI: | 10.1186/s12944-020-01339-y |
| الاتاحة: | https://doi.org/10.1186/s12944-020-01339-y https://doaj.org/article/c0ac868fe1a246bf9aaa759322cdb44c |
| رقم الانضمام: | edsbas.D92CAA9C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1476511X |
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| DOI: | 10.1186/s12944-020-01339-y |