Academic Journal
O-072 Lack of meaningful impact of male body mass index (BMI) on reproductive outcomes measured by cumulative live birth rates (CLBR) in 80830 IVF-ICSI treatments
| العنوان: | O-072 Lack of meaningful impact of male body mass index (BMI) on reproductive outcomes measured by cumulative live birth rates (CLBR) in 80830 IVF-ICSI treatments |
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| المؤلفون: | Mossetti, L, Hervás Herrero, I, Gil Julia, M, Navarro Gómez-Lechón, A, Pacheco Rendón, R M, Rivera Egea, R, Garrido Puchalt, N |
| المصدر: | Human Reproduction ; volume 38, issue Supplement_1 ; ISSN 0268-1161 1460-2350 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| الوصف: | Study question Does men’s BMI influence the reproductive success measured as CLBR per embryo transfer(ET), embryos replaced(EmbR) and oocytes utilized, if female BMI is controlled? Summary answer Male’s BMI do not affect reproductive outcomes, although obese males seem to need slightly more ET to reach the first live birth. What is known already Obesity is a systemic, chronic and multifactorial disease present worldwide, involving all ages, ethnicities and social classes, and associated with hormonal alterations that may lead to a decrease in seminal quality and reproductive outcomes. The exact mechanisms involved, between excess body fat and reproductive disturbances, if any, are complex and unknown. This leads us to investigate the effect of BMI on reproductive outcomes to carry out a better counseling of couples who go to a clinic for assisted reproduction treatment. The recent improvement of measuring reproductive success by cumulative rates has never been applied to many risk factors, as obesity. Study design, size, duration This retrospective observational multicentric study has evaluated the results from 80830 IVF-ICSI treatments, 298422 oocytes and 215357 embryos transferred performed in Spanish IVIRMA fertility clinics between January 2008 and December 2020 by couples using their own sperm sample and oocytes. Participants/materials, setting, methods Couples attending IVI clinics. Male BMI was categorized in: underweight (<18.5 kg/m2) (U), normal weight (18.5-24.99 kg/m2) (N), overweight (25-29.99 kg/m2) (OV) and obese (≥ 30 kg/m2) (OB) patients, and CLBR were calculated using Kaplan Meier methods, by Cox regression to control women’s BMI and age, and male’s age. Reproductive success was calculated by CLBR perET, EmbR and utilized oocytes until the first LB. Data were expressed as % with corresponding 95% confidence intervals. Main results and the role of chance After 3 ETs, CLBR per ET, were, for groups U,N,OV and OB, respectively, 47.4%(44.3-50.3), 48.1%(47.4-48.9), 47.8%(46.2-49.4) and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/humrep/dead093.086 |
| الاتاحة: | https://doi.org/10.1093/humrep/dead093.086 https://academic.oup.com/humrep/article-pdf/38/Supplement_1/dead093.086/50786786/dead093.086.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.D89ADB90 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/humrep/dead093.086 |
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