Academic Journal
Ramadan Intermittent Fasting Affects Adipokines and Leptin/Adiponectin Ratio in Type 2 Diabetes Mellitus and Their First‐Degree Relatives
| العنوان: | Ramadan Intermittent Fasting Affects Adipokines and Leptin/Adiponectin Ratio in Type 2 Diabetes Mellitus and Their First‐Degree Relatives |
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| المؤلفون: | Abdullah, Khaldoon, AL-Habori, Molham, Al-Eryani, Ekram |
| المساهمون: | Prodam, Flavia |
| المصدر: | BioMed Research International ; volume 2020, issue 1 ; ISSN 2314-6133 2314-6141 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background . In view of the association of Ramadan intermittent fasting with profound changes in lifestyle both in nondiabetic and diabetic patients, the aim of this study was to investigate the effect of Ramadan fasting on adiponectin, leptin and leptin to adiponectin ratio (LAR), growth hormone (GH), human‐sensitive C‐reactive protein (hs‐CRP), and diabetic and metabolic syndrome factors in patients with Type 2 Diabetes Mellitus (Type 2 DM), their first‐degree relatives (FDRs), and healthy controls. Methods . This cohort study involved 98 Yemeni male subjects aged 30‐70 years old: 30 Type 2 DM, 37 FDRs of Type 2 diabetic patients, and 31 healthy control subjects. Subjects’ body mass index (BMI), waist circumference (WC), and blood pressure (BP) were measured, and venous blood samples were collected twice: the first samples were collected a couple of days prior to Ramadan fasting (baseline) and the second samples after 3 weeks of fasting. Results . Ramadan fasting did not affect BMI, WC, and BP in Type 2 DM and their FDRs with respect to the baseline levels prior to Ramadan, whereas triglyceride and cholesterol were borderline significantly decreased in Type 2 DM with no effect in FDRs. Fasting blood glucose was not affected in Type 2 DM but was significantly increased in FDRs and control groups, whereas glycated haemoglobin (HbA1c) was slightly decreased in Type 2 DM, FDRs, and healthy controls. C‐peptide, insulin, and insulin resistance (HOMA‐IR) were significantly increased in Type 2 DM and FDRs, with no effect in the control group, whereas β ‐cell function (HOMA‐ β ) was significantly decreased in FDRs and controls with no change in Type 2 DM. Ramadan fasting significantly decreased GH in both FDRs and control groups, and significantly increased hs‐CRP in the control with no effect in Type 2 DM and FDRs. Adiponectin was significantly decreased, and leptin and LAR were significantly increased in Type 2 DM, FDRs, and control groups. Conclusion . Ramadan intermittent fasting decreased adiponectin and increased ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1155/2020/1281792 |
| الاتاحة: | https://doi.org/10.1155/2020/1281792 http://downloads.hindawi.com/journals/bmri/2020/1281792.pdf http://downloads.hindawi.com/journals/bmri/2020/1281792.xml https://onlinelibrary.wiley.com/doi/pdf/10.1155/2020/1281792 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.D882D911 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2020/1281792 |
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