Academic Journal
Changes in serum DAMPs and cytokines/chemokines during near‐infrared photoimmunotherapy for patients with head and neck cancer
| العنوان: | Changes in serum DAMPs and cytokines/chemokines during near‐infrared photoimmunotherapy for patients with head and neck cancer |
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| المؤلفون: | Ishihara, Hiromasa, Nishikawa, Daisuke, Muraoka, Daisuke, Masago, Katsuhiro, Beppu, Shintaro, Terada, Hoshino, Matsushita, Hirokazu, Hanai, Nobuhiro |
| المساهمون: | Japan Society for the Promotion of Science |
| المصدر: | Cancer Medicine ; volume 13, issue 1 ; ISSN 2045-7634 2045-7634 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Near‐infrared photoimmunotherapy (NIR‐PIT) for head and neck cancer is a recently developed therapy. However, there is limited data on patients receiving NIR‐PIT in real clinical settings. Methods Seven NIR‐PIT sessions were administered to five patients with head and neck squamous cell carcinoma (HNSCC). Serum damage‐associated molecular patterns (DAMPs) (HMGB1 and Hsp70 levels), and cytokine and chemokine production, were compared before and after NIR‐PIT. Results The serum concentration of HMGB1 increased after NIR‐PIT ( p = 0.031, Wilcoxon test) in all patients except one who did not achieve a clinical response. Chemokines MIP‐1α (CCL3) and MIP‐1β (CCL4) increased significantly 1–3 days after treatment (CCL3, p = 0.0036; CCL4, p = 0.0016, Wilcoxon test). A low pre‐treatment neutrophil‐to‐lymphocyte ratio (NLR) was associated with a better response to therapy and survival. Conclusions The release of DAMPs, and cytokine/chemokine production, were detected in the patients' peripheral blood. The baseline NLR may predict patient outcomes in response to NIR‐PIT. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/cam4.6863 |
| الاتاحة: | http://dx.doi.org/10.1002/cam4.6863 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.6863 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.D867AA0C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cam4.6863 |
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