Academic Journal
Risk of tumor lysis syndrome in patients with acute myeloid leukemia treated with venetoclax-containing regimens without dose ramp-up
| العنوان: | Risk of tumor lysis syndrome in patients with acute myeloid leukemia treated with venetoclax-containing regimens without dose ramp-up |
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| المؤلفون: | Shahswar, Rabia, Beutel, Gernot, Gabdoulline, Razif, Koenecke, Christian, Markel, Dominik, Eder, Matthias, Stadler, Michael, Gohring, Gudrun, Schlegelberger, Brigitte, Trummer, Arne, Krauter, Juergen, Thol, Felicitas, Heuser, Michael |
| المصدر: | http://lobid.org/resources/99370678538206441#!, 100(2):595-599. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Bridged Bicyclo Compounds, Heterocyclic/adverse effects [MeSH], Female [MeSH], Antineoplastic Agents/adverse effects [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], Heterocyclic/administration, Adult [MeSH], Cytarabine/therapeutic use [MeSH], Azacitidine/therapeutic use [MeSH], Humans [MeSH], Middle Aged [MeSH], Risk Factors [MeSH], Letter to the Editor, Oncology, Sulfonamides/administration, Decitabine/therapeutic use [MeSH], Hematology, Sulfonamides/adverse effects [MeSH], Male [MeSH], Antineoplastic Agents/therapeutic use [MeSH], Leukemia, Myeloid, Acute/drug therapy [MeSH], Acute/physiopathology [MeSH], Tumor Lysis Syndrome/etiology [MeSH] |
| الوصف: | Resistant disease is still a main obstacle in acute myeloid leukemia (AML) treatment. Therefore, individual genetic variations affecting therapy response are gaining increasing importance. Both SNPs and ABC transporter genes could already be associated with drug resistance. Here, we report allelic variants of MRP1 (ABCC1) SNPs rs129081, rs212090, and rs212091 with significant influences on survival in AML patients. DNA was extracted from bone marrow samples (n = 160) at diagnosis. Genotyping 48 SNPs within seven different ABC transporter genes using real-time PCR revealed rs129081 GG variant with a significant higher OS (p = 0.035) and DFS (p = 0.01). Comparing TT and AA rs212090 variants showed significant influences on DFS (p = 0.021). SNP rs212091 GG expression was associated with worse OS (p = 0.006) and a significant difference in DFS between alleles GG and AA (p = 0.018). The multivariable models confirmed a significant influence on OS for rs212091 (AA HR = 0.296, 95% CI 0.113-0.774, p = 0.013 and GG p = 0.044). Rs129081 variant CG, TT of rs212090, AA, and AG of rs212091 demonstrated significant impact on DFS (p = 0.024, p = 0.029, p = 0.017, and p = 0.042, respectively). This analysis demonstrates a significant influence of MRP1 SNPs on survival in AML. As they were not associated to prognostic characteristics, we suggest these SNPs to be independent prognostic markers for AML. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6466988; https://doi.org/10.1007/s00277-020-04181-5; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817590/ |
| DOI: | 10.1007/s00277-020-04181-5 |
| الاتاحة: | https://repository.publisso.de/resource/frl:6466988 https://doi.org/10.1007/s00277-020-04181-5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817590/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.D8397628 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00277-020-04181-5 |
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