Academic Journal
Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
| العنوان: | Association of metabolic gene polymorphisms with tobacco consumption in healthy controls |
|---|---|
| المؤلفون: | Smits KM, Benhamou S, Garte S, Weijenberg MP, Alamanos Y, Ambrosone C, Autrup H, Autrup JL, Baranova H, Bathum L, Boffetta P, Bouchardy C, Brockmoller J, Butkiewicz D, Cascorbi I, Clapper ML, Coutelle C, Daly AK, Dolzan V, Duzhak TG, Farker K, Golka K, Haugen A, Hein DW, Hildesheim A, Hirvonen A, Hsieh LL, Ingelman Sundberg M, Kalina I, Kang D, Katoh T, Kihara M, Ono Kihara M, Kim H, Kiyohara C, Kremers P, Lazarus P, Le Marchand L, Lechner MC, London S, Manni JJ, Maugard CM, Morgan GJ, Morita S, Nazar Stewart V, Kristensen VN, Oda Y, Parl FF, Peters WH, Rannug A, Rebbeck T, Pinto LF, Risch A, Romkes M, Salagovic J, Schoket B, Seidegard J, Shields PG, Sim E, Sinnett D, Strange RC, Stucker I, Sugimura H, To Figueras J, Vineis P, Yu MC, Zheng W, Pedotti P, Taioli E., MUZI, Giacomo |
| المساهمون: | Smits, Km, Benhamou, S, Garte, S, Weijenberg, Mp, Alamanos, Y, Ambrosone, C, Autrup, H, Autrup, Jl, Baranova, H, Bathum, L, Boffetta, P, Bouchardy, C, Brockmoller, J, Butkiewicz, D, Cascorbi, I, Clapper, Ml, Coutelle, C, Daly, Ak, Muzi, Giacomo, Dolzan, V, Duzhak, Tg, Farker, K, Golka, K, Haugen, A, Hein, Dw, Hildesheim, A, Hirvonen, A, Hsieh, Ll, Ingelman Sundberg, M, Kalina, I, Kang, D, Katoh, T, Kihara, M, Ono Kihara, M, Kim, H, Kiyohara, C, Kremers, P, Lazarus, P, Le Marchand, L, Lechner, Mc, London, S, Manni, Jj, Maugard, Cm, Morgan, Gj, Morita, S, Nazar Stewart, V, Kristensen, Vn, Oda, Y, Parl, Ff, Peters, Wh, Rannug, A, Rebbeck, T, Pinto, Lf, Risch, A, Romkes, M, Salagovic, J, Schoket, B, Seidegard, J, Shields, Pg, Sim, E, Sinnett, D, Strange, Rc, Stucker, I, Sugimura, H, To Figueras, J, Vineis, P, Yu, Mc, Zheng, W, Pedotti, P, Taioli, E. |
| سنة النشر: | 2004 |
| المجموعة: | IRIS Università degli Studi di Perugia |
| الوصف: | Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000221181500017; volume:110; firstpage:266; lastpage:270; numberofpages:5; journal:INTERNATIONAL JOURNAL OF CANCER; http://hdl.handle.net/11391/14564; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-2342612759 |
| الاتاحة: | http://hdl.handle.net/11391/14564 |
| رقم الانضمام: | edsbas.D82EE28 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |