Academic Journal
One-Pot Fabrication of Supramolecular Synthetic Protein Hydrogel with Tissue-like Integrated Dynamic Features
| العنوان: | One-Pot Fabrication of Supramolecular Synthetic Protein Hydrogel with Tissue-like Integrated Dynamic Features |
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| المؤلفون: | Chendi Gao, Ensong Zhang, Xinyu Bian, Qiaoran Li, Chunming Wang, Guang Yang, Ming Jiang, Guosong Chen |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Medicine, Genetics, Molecular Biology, Pharmacology, Biotechnology, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, received remarkable attention, past several years, networks may result, material demonstrated potential, incorporated soft networks, including remarkable stretchability, exhibit unique advantages, highly efficient method, include supramolecular interactions, complex protein mutation, supramolecular interactions, ultrafast self, strategy provides, satisfactory ability, protein hydrogel, pot polymerization, original length, nonliving substrates, new avenue |
| الوصف: | Protein-incorporated soft networks have received remarkable attention during the past several years. They possess desirable properties similar to native tissues and organs and exhibit unique advantages in applications. However, fabrication of protein-based hydrogels usually suffers from complex protein mutation and modification or chemical synthesis, which limited the scale and yield of production. Meanwhile, the lack of rationally designed noncovalent interactions in networks may result in a deficiency of the dynamic features of materials. Therefore, a highly efficient method is needed to include supramolecular interactions into protein hydrogel to generate a highly dynamic hydrogel possessing integrated tissue-like properties. Here, we report the design and construction of native protein-based supramolecular synthetic protein hydrogels through a simple and efficient one-pot polymerization of acrylamide and ligand monomers in the presence of a ligand-binding protein. The supramolecular interactions in the network yield integrated dynamic properties, including remarkable stretchability over 10,000% of their original length, ultrafast self-healing abilities within 3–4 s, tissue-like fast stress relaxation, satisfactory ability of adhesion to different living and nonliving substrates, injectability, and high biocompatibility. Furthermore, this material demonstrated potential as a biosensor to monitor small finger movements. This strategy provides a new avenue for fabricating synthetic protein hydrogels with integrated features. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/One-Pot_Fabrication_of_Supramolecular_Synthetic_Protein_Hydrogel_with_Tissue-like_Integrated_Dynamic_Features/25267283 |
| DOI: | 10.1021/acs.biomac.3c01451.s001 |
| الاتاحة: | https://doi.org/10.1021/acs.biomac.3c01451.s001 https://figshare.com/articles/journal_contribution/One-Pot_Fabrication_of_Supramolecular_Synthetic_Protein_Hydrogel_with_Tissue-like_Integrated_Dynamic_Features/25267283 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.D7F6ED8E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.biomac.3c01451.s001 |
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