Academic Journal
Oral colonization by levilactobacillus brevis KABPTM-052 and Lactiplantibacillus plantarum KABPTM-051: a randomized, double-blinded, placebo-controlled trial (pilot study)
| العنوان: | Oral colonization by levilactobacillus brevis KABPTM-052 and Lactiplantibacillus plantarum KABPTM-051: a randomized, double-blinded, placebo-controlled trial (pilot study) |
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| المؤلفون: | Nart Molina, José, Jiménez-Garrido, Sara, Ramírez Sebastià, Anaïs, Astó, Erola, Buj, David, Huedo, Pol, Espadaler Mazo, Jordi |
| بيانات النشر: | Medicina Oral S.L. |
| سنة النشر: | 2021 |
| المجموعة: | UIC Open Access Archive (Universitat Internacional de Catalunya) |
| مصطلحات موضوعية: | Probiòtics, Odontologia, Periodòncia, Saliva, Microbiota oral, Placa dental, Probióticos, Odontología, Periodoncia, Probiotics, Dentistry, Periodontics, Oral microbiota, Dental plaque, 616.3 |
| الوصف: | Background: To determine the oral colonization capacity of the strains Levilactobacillus brevis KABPTM-052 (CECT 7480) and Lactiplantibacillus plantarum KABPTM-051 (CECT 7481) in healthy subjects. Material and Methods: This randomized, double-blinded, placebo-controlled study included 40 volunteers (22 females, 18 males; age range 18-55 years) with healthy gingiva or mild gingivitis, allocated to receiving probiotic chewing gum (n=20) or placebo (n=20) b.i.d for 6 weeks. At baseline and after 6 weeks of treatment, a periodontics specialist collected saliva samples to assess probiotic colonization by qPCR, and analysed dental plaque, gingival index and dental probing pocket depth in Community Periodontal Index (CPI) teeth subset. Protocol was registered as NCT03540498. Results: Treatment compliance was high (99%). Both L. brevis and L. plantarum were detected in the oral microbiota at baseline. After 6 weeks, volunteers receiving probiotic showed a significant increase of both L. brevis (p = 0.017) and L. plantarum (p = 0.004) versus placebo. This effect remained significant after adjusting for gender and gingival index at baseline. In the probiotic group, reduction in plaque index significantly correlated to higher levels of L. brevis (rho = 0.57, p = 0.022) but not of L. plantarum at study endpoint, and the number of subjects with dental plaque was reduced during intervention (7 of 17, p = 0.016). No such effects were observed in the placebo group. No adverse drug reactions were reported. Conclusions: Levilactobacillus brevis KABPTM-052 and Lactiplantibacillus plantarum KABPTM-051 colonize the buccal microbiota of healthy volunteers, and higher colonization by L. brevis positively correlated to reduction in dental plaque. ; info:eu-repo/semantics/publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1989-5488 |
| Relation: | Journal of Clinical and Experimental Dentistry; 13;5; Nart Molina, José; Jiménez-Garrido, Sara; Ramírez-Sebastià, Anaïs [et al.]. Oral colonization by levilactobacillus brevis KABPTM-052 and Lactiplantibacillus plantarum KABPTM-051: a randomized, double-blinded, placebo-controlled trial (pilot study). Journal of Clinical and Experimental Dentistry, 2021, 13(5), e433-439. Disponible en: . Fecha de acceso: 1 jun. 2021. DOI:10.4317/jced.57771; http://hdl.handle.net/20.500.12328/2578; https://dx.doi.org/10.4317/jced.57771 |
| DOI: | 10.4317/jced.57771 |
| الاتاحة: | https://hdl.handle.net/20.500.12328/2578 https://doi.org/10.4317/jced.57771 |
| Rights: | © 2021 Medicina Oral S.L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ; https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D79CE2D5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19895488 |
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| DOI: | 10.4317/jced.57771 |