Academic Journal
Klebsiella oxytoca facilitates microbiome recovery via antibiotic degradation and restores colonization resistance in a diet-dependent manner
| العنوان: | Klebsiella oxytoca facilitates microbiome recovery via antibiotic degradation and restores colonization resistance in a diet-dependent manner |
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| المؤلفون: | Almási, Éva d. H., Eisenhard, Lea, Osbelt, Lisa, Lesker, Till Robin, Vetter, Anna C., Knischewski, Nele, Bielecka, Agata Anna, Gronow, Achim, Muthukumarasamy, Uthayakumar, Wende, Marie, Tawk, Caroline, Neumann-Schaal, Meina, Brönstrup, Mark, Strowig, Till |
| المساهمون: | Joint Programming Initiative on Antimicrobial Resistance, Bundesministerium für Bildung und Forschung, Deutsches Zentrum für Infektionsforschung, Deutsche Forschungsgemeinschaft |
| المصدر: | Nature Communications ; volume 16, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2025 |
| الوصف: | Competition among bacteria for carbohydrates is pivotal for colonization resistance (CR). However, the impact of Western-style diets on CR remains unclear. Here we show how the competition between Klebsiella oxytoca and Klebsiella pneumoniae is modulated by consuming one of three Western-style diets characterized by high-starch, high-sucrose, or high-fat/high-sucrose content. In vivo competition experiments in ampicillin-treated mice reveal that K. oxytoca promotes K. pneumoniae decolonization on all dietary backgrounds. However, mice on the high-fat/high-sucrose diet show reduced pathogen clearance. Microbiome analysis reveals that the combination of Western-style diets and ampicillin treatment synergize in microbiome impairment, particularly noticeable in the presence of high dietary fat content. The diet-independent degradation of ampicillin in the gut lumen by K. oxytoca beta-lactamases facilitates rapid commensal outgrowth, which is required for subsequent pathogen clearance. Our findings provide insights into how diet modulates functional microbiome recovery and K. oxytoca -mediated pathogen elimination from the gut. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-024-55800-y |
| الاتاحة: | https://doi.org/10.1038/s41467-024-55800-y https://www.nature.com/articles/s41467-024-55800-y.pdf https://www.nature.com/articles/s41467-024-55800-y |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.D76803F9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-024-55800-y |
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