Academic Journal
Persistent intracranial hyper-inflammation in ruptured cerebral aneurysm after COVID-19: case report and review of the literature
| العنوان: | Persistent intracranial hyper-inflammation in ruptured cerebral aneurysm after COVID-19: case report and review of the literature |
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| المؤلفون: | Chong, Pin Fee, Higashi, Kanako, Matsuoka, Wakato, Arimura, Koichi, Sangatsuda, Yuhei, Iwaki, Katsuma, Sonoda, Yuri, Ichimiya, Yuko, Kamori, Akiko, Kawakami, Akiko, Mizuguchi, Soichi, Kaku, Noriyuki, Sakai, Yasunari, Ohga, Shouichi |
| المساهمون: | Japan Society for the Promotion of Science, Ministry of Health, Labour and Welfare, Japan Agency for Medical Research and Development, Japan Epilepsy Research Foundation, Kawano Masanori Memorial Public Interest Incorporated Foundation |
| المصدر: | BMC Neurology ; volume 24, issue 1 ; ISSN 1471-2377 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| الوصف: | Background The systemic manifestations of coronavirus disease 2019 (COVID-19) include hyperinflammatory reactions in various organs. Recent studies showed evidence for the frequent involvement of central nervous system in affected patients; however, little is known about clinical features of cerebrovascular diseases in childhood-onset COVID-19. Case presentation A 10-year-old boy recovered from SARS-CoV-2 infection without complication. On 14 days after infection, he presented with loss of consciousness. A head computed tomography detected a ruptured cerebral aneurysm at the left posterior cerebral artery accompanying subarachnoid hemorrhage (SAH). Immediate surgical intervention did not rescue the patient, resulting in the demise 7 days after admission. Serological and genetic tests excluded the diagnosis of vasculitis and connective tissue disorders. Retrospective analysis showed markedly higher levels of interleukin (IL)-1β, IL-6 and IL-8 in the cerebrospinal fluid than the serum sample concurrently obtained. A review of literature indicated that adult patients with COVID-19 have a risk for the later development of SAH during the convalescent phase of COVID-19. Conclusions SAH is a severe complication of COVID-19 in children and adults who have asymptomatic cerebrovascular aneurysms. The markedly high levels of cytokines detected in the cerebrospinal fluid suggested that intracranial hyperinflammatory condition might be one of the possible mechanisms involved in the rupture of a preexisting cerebrovascular aneurysms. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12883-023-03493-z |
| DOI: | 10.1186/s12883-023-03493-z.pdf |
| DOI: | 10.1186/s12883-023-03493-z/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12883-023-03493-z https://link.springer.com/content/pdf/10.1186/s12883-023-03493-z.pdf https://link.springer.com/article/10.1186/s12883-023-03493-z/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.D752855C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12883-023-03493-z |
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