التفاصيل البيبلوغرافية
| العنوان: |
Additional file 6 of Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models |
| المؤلفون: |
Camilla Coulson-Gilmer (11572995), Robert D. Morgan (10517033), Louisa Nelson (9620785), Bethany M. Barnes (11375268), Anthony Tighe (34618), René Wardenaar (3595967), Diana C. J. Spierings (11510967), Helene Schlecht (11572998), George J. Burghel (11375271), Floris Foijer (3421868), Sudha Desai (589177), Joanne C. McGrail (11375274), Stephen S. Taylor (7184861) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, High-grade serous ovarian cancer, PARG inhibitor, DNA replication, Replication stress, Gene expression signature, Predictive biomarkers |
| الوصف: |
Additional file 6: Fig. S6. Living biobank screen demonstrated broad range of PARGi and PARPi sensitivity. (A) Colony formation following 96 h of treatment with 1 μM PARGi or 1 μM PARPi or DMSO (Control). (B) Quantification of ca from (A) following 1 μM PARGi (B) or 1 μM PARPi (C), normalised to DMSO-treated cells (Control) and represented as fold-change. BRCA status (germline, or, where available, OCM) indicated as follows: + = BRCA status of OCM; W=BRCA1/2 wild-type; B=BRCA1/2 mutation; V=BRCA1/2 variant of uncertain clinical significance; R = putative BRCA1/2 reversion; ▼=prior PARPi therapy. Single technical replicate. (D) Exemplar images of colony formation following continuous treatment with 1 μM PARGi or 1 μM PARPi or DMSO (Control). Representative images of 3 biological replicates. (E) Quantification of ca from (D) normalised to DMSO-treated cells (Control) and represented as fold-change. Mean of 3 biological replicates. Error bars represent SEM. See also Supplementary Table 2 and Fig. 5A, B. ***p < 0.001, ****p < 0.0001. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Additional_file_6_of_Replication_catastrophe_is_responsible_for_intrinsic_PAR_glycohydrolase_inhibitor-sensitivity_in_patient-derived_ovarian_cancer_models/16822761 |
| DOI: |
10.6084/m9.figshare.16822761.v1 |
| الاتاحة: |
https://doi.org/10.6084/m9.figshare.16822761.v1 |
| Rights: |
CC BY + CC0 |
| رقم الانضمام: |
edsbas.D7482F6F |
| قاعدة البيانات: |
BASE |