Academic Journal
Lower Efficacy in the Utilization of Dietary ALA as Compared to Preformed EPA + DHA on Long Chain n-3 PUFA Levels in Rats
| العنوان: | Lower Efficacy in the Utilization of Dietary ALA as Compared to Preformed EPA + DHA on Long Chain n-3 PUFA Levels in Rats |
|---|---|
| المؤلفون: | Ramaprasad, T. R., Baskaran, V., Kari, Sambaiah, Lokesh, B. R. |
| سنة النشر: | 2010 |
| المجموعة: | Central Food Technological Research Institute, New Delhi: ePrints@CFTRI |
| مصطلحات موضوعية: | 22 Lipid Chemistry |
| الوصف: | We made a comparative analysis of the uptake, tissue deposition and conversion of dietary a-linolenic acid (ALA) to its long chain metabolites eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with preformed EPA ? DHA. Diets containing linseed oil [with ALA at *2.5 (4 g/kg diet), 5 (8 g/kg diet), 10 (16 g/kg diet), 25% (40 g/kg diet)] or fish oil [with EPA ? DHA at *1 (1.65 g/kg diet), 2.5 (4.12 g/kg diet), 5% (8.25 g/kg diet)] or groundnut oil without n-3 polyunsaturated fatty acids (n-3 PUFA) were fed to rats for 60 days. ALA and EPA ? DHA in serum, liver, heart and brain increased with increments in the dietary ALA level. When preformed EPA ? DHA were fed, the tissue EPA ? DHA increased significantly compared to those given ALA. Normalized values from dietary n-3 PUFA to tissue EPA ? DHA indicated that 100 mg of dietary ALA lead to accumulation of EPA ? DHA at 2.04, 0.70, 1.91 and 1.64% of total fatty acids respectively in liver, heart, brain and serum. Similarly 100 mg of preformed dietary EPA ? DHA resulted in 25.4, 23.8, 15.9 and 14.9% of total fatty acids in liver, heart, brain and serum respectively. To maintain a given level of EPA ? DHA, the dietary ALA required is 12.5, 33.5, 8.3 and 9.1 times higher than the dietary EPA ? DHA for liver, heart, brain and serum respectively. Hence the efficacy of precursor ALA is lower compared to preformed EPA ? DHAin elevating serum and tissue long chain n-3 PUFA levels. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://ir.cftri.res.in/9737/1/Lipids,_2010,_Volume_45,_Number_9,_Pages_799-808.pdf; Ramaprasad, T. R. and Baskaran, V. and Kari, Sambaiah and Lokesh, B. R. (2010) Lower Efficacy in the Utilization of Dietary ALA as Compared to Preformed EPA + DHA on Long Chain n-3 PUFA Levels in Rats. Lipids , 45. pp. 799-808. |
| الاتاحة: | http://ir.cftri.res.in/9737/ http://ir.cftri.res.in/9737/1/Lipids,_2010,_Volume_45,_Number_9,_Pages_799-808.pdf |
| رقم الانضمام: | edsbas.D70E6A4E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |