Academic Journal
Intestinal dual-specificity phosphatase 6 regulates the cold-induced gut microbiota remodeling to promote white adipose browning
| العنوان: | Intestinal dual-specificity phosphatase 6 regulates the cold-induced gut microbiota remodeling to promote white adipose browning |
|---|---|
| المؤلفون: | Chen, Pei-Chen, Tsai, Tzu-Pei, Liao, Yi-Chu, Liao, Yu-Chieh, Cheng, Hung-Wei, Weng, Yi-Hsiu, Lin, Chiao-Mei, Kao, Cheng-Yuan, Tai, Chih-Cheng, Ruan, Jhen-Wei |
| المصدر: | npj Biofilms and Microbiomes ; volume 10, issue 1 ; ISSN 2055-5008 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| الوصف: | Gut microbiota rearrangement induced by cold temperature is crucial for browning in murine white adipose tissue. This study provides evidence that DUSP6, a host factor, plays a critical role in regulating cold-induced gut microbiota rearrangement. When exposed to cold, the downregulation of intestinal DUSP6 increased the capacity of gut microbiota to produce ursodeoxycholic acid (UDCA). The DUSP6-UDCA axis is essential for driving Lachnospiraceae expansion in the cold microbiota. In mice experiencing cold-room temperature (CR) transitions, prolonged DUSP6 inhibition via the DUSP6 inhibitor (E/Z)-BCI maintained increased cecal UDCA levels and cold-like microbiota networks. By analyzing DUSP6-regulated microbiota dynamics in cold-exposed mice, we identified Marvinbryantia as a genus whose abundance increased in response to cold exposure. When inoculated with human-origin Marvinbryantia formatexigens , germ-free recipient mice exhibited significantly enhanced browning phenotypes in white adipose tissue. Moreover, M. formatexigens secreted the methylated amino acid Nε-methyl-L-lysine, an enriched cecal metabolite in Dusp6 knockout mice that reduces adiposity and ameliorates nonalcoholic steatohepatitis in mice. Our work revealed that host-microbiota coadaptation to cold environments is essential for regulating the browning-promoting gut microbiome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41522-024-00495-8 |
| الاتاحة: | http://dx.doi.org/10.1038/s41522-024-00495-8 https://www.nature.com/articles/s41522-024-00495-8.pdf https://www.nature.com/articles/s41522-024-00495-8 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.D70D4B6B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41522-024-00495-8 |
|---|