Academic Journal
No evidence for viral sequences in five lepidic adenocarcinomas (former “BAC”) by a high-throughput sequencing approach
| العنوان: | No evidence for viral sequences in five lepidic adenocarcinomas (former “BAC”) by a high-throughput sequencing approach |
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| المؤلفون: | Berthet, Nicolas, Frangeul, L., Olaussen, Ken André, Brambilla, Elisabeth, Dorvault, Nicolas, Girard, Philippe, Validire, Pierre, Fadel, Elie, Bouchier, Christiane, Gessain, Antoine, Soria, Jean-Charles |
| المساهمون: | Epidémiologie et Physiopathologie des Virus Oncogènes (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur Paris (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Virus et Interférence ARN - Viruses and RNA Interference, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Biomarqueurs prédictifs et nouvelles stratégies moléculaires en thérapeutique anticancéreuse (U981), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Michallon, Institut Mutualiste de Montsouris (IMM), Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique (HPPIT), Université Paris-Sud - Paris 11 (UP11)-Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11), Génomique (Plate-Forme) - Genomics Platform, Institut Pasteur Paris (IP) |
| المصدر: | ISSN: 1756-0500 ; BMC Research Notes ; https://pasteur.hal.science/pasteur-03252015 ; BMC Research Notes, 2015, 8 (1), pp.782. ⟨10.1186/s13104-015-1669-8⟩. |
| بيانات النشر: | CCSD BioMed Central |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Lung Adenocarcinoma, Merkel Cell Carcinoma, Oncogenic Virus, Taxonomic Assignment, Primary Effusion Lymphoma, MESH: Adenocarcinoma, Bronchiolo-Alveolar, MESH: Female, MESH: High-Throughput Nucleotide Sequencing, MESH: Humans, MESH: Jaagsiekte sheep retrovirus, MESH: Lung, MESH: Lung Neoplasms, MESH: Male, MESH: Middle Aged, MESH: Pulmonary Adenomatosis, Ovine, MESH: Sheep, MESH: Aged, MESH: Animals, MESH: Endogenous Retroviruses, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| الوصف: | International audience ; BackgroundThe hypothesis of an infectious etiology of the formerly named bronchiolo-alveolar carcinoma (BAC) has raised controversy. We investigated tumor lung tissues from five patients with former BAC histology using high-throughput sequencing technologies to discover potential viruses present in this type of lung cancer. Around 180 million single reads of 100 bases were generated for each BAC sample.ResultsNone of the reads showed a significant similarity for Jaagsiekte sheep retrovirus (JSRV) and no other viruses were found except for endogenous retroviruses.ConclusionsIn conclusion, we have demonstrated the absence of JSRV and other known human viruses in five samples of well-characterized lepidic adenocarcinoma.BackgroundThe bronchiolar-alveolar cancer (BAC) in its past definition (WHO classification 1999) is a rare form of lung adenocarcinoma (ADC). The international WHO 2015 classification recommends distinguishing adenocarcinoma in situ (AIS, formerly non-mucinous BAC) from invasive mucinous adenocarcinoma (IMA, formerly mucinous BAC) and non-mucinous lepidic predominant invasive adenocarcinoma of the lungs [1]. In many such patients, the tumor progression respects the pulmonary architecture and develops mainly in the terminal respiratory unit (lepidic growth). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/26667652; PUBMED: 26667652; PUBMEDCENTRAL: PMC4678645 |
| DOI: | 10.1186/s13104-015-1669-8 |
| الاتاحة: | https://pasteur.hal.science/pasteur-03252015 https://pasteur.hal.science/pasteur-03252015v1/document https://pasteur.hal.science/pasteur-03252015v1/file/s13104-015-1669-8.pdf https://doi.org/10.1186/s13104-015-1669-8 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.D6CABFA0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13104-015-1669-8 |
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