Academic Journal
Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS:A systematic review and meta-regression
| العنوان: | Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS:A systematic review and meta-regression |
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| المؤلفون: | Kakoly, N. S., Khomami, M. B., Joham, A. E., Cooray, S. D., Misso, M. L., Norman, R. J., Harrison, C. L., Ranasinha, S., Teede, H. J., Moran, L. J. |
| المصدر: | Kakoly , N S , Khomami , M B , Joham , A E , Cooray , S D , Misso , M L , Norman , R J , Harrison , C L , Ranasinha , S , Teede , H J & Moran , L J 2018 , ' Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS : A systematic review and meta-regression ' , Human Reproduction Update , vol. 24 , no. 4 , pp. 455-467 . https://doi.org/10.1093/humupd/dmy007 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Impaired glucose tolerance, Meta-analysis, Meta-regression, Polycystic ovary syndrome, Type 2 diabetes mellitus |
| الوصف: | BACKGROUND: Our prior meta-analyses demonstrated an increased prevalence of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) with polycystic ovary syndrome (PCOS), but with substantial clinical heterogeneity. OBJECTIVE AND RATIONALE: We aimed to update our previous review to quantify the prevalence of IGT and T2DM in PCOS with only quality studies (good and fair quality). We also aimed to examine the contribution of parameters including ethnicity, obesity and method of diagnosing T2DM in explaining the observed heterogeneity in IGT and T2DM prevalence in PCOS. SEARCH METHODS: We conducted a literature search (MEDLINE, CINAHL, EMBASE, clinical trial registries and hand-searching) up to June 2016 to identify studies reporting the prevalence of dysglycemia (IGT and T2DM) in women with and without PCOS. We included studies where women with PCOS (defined according to original National Institute of Health) were compared to women without PCOS for the end-points of the prevalence of IGT or T2DM. We excluded case reports, case series, editorials, and narrative reviews. Studies where PCOS was diagnosed by self-report, or where IGT or T2DM were measured by fasting glucose, only were excluded. We assessed the methodological quality of the included studies using a priori criteria based on the Newcastle-Ottawa Scaling (NOS) for nonrandomized studies. Data are presented as odds ratio (OR) (95% CI) with random-effects meta-analysis by Mantel-Haenszel methods. We assessed the contribution of demographic and clinical factors to heterogeneity using subgroup and meta-regression analysis. OUTCOMES: We reviewed 4530 studies and included 40 eligible studies in the final analysis. On meta-analysis of quality studies, women with PCOS had an increased prevalence of IGT (OR = 3.26, 95% CI: 2.17-4.90) and T2DM (OR = 2.87, 95% CI: 1.44-5.72), which differed by ethnicity (for IGT, Asia: 5-fold, the Americas: 4-fold and Europe: 3-fold), was higher with obesity, and doubled among studies using self-report or administrative ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1093/humupd/dmy007 |
| الاتاحة: | https://research.monash.edu/en/publications/cb683234-9f45-4ded-b6ae-541ca0160376 https://doi.org/10.1093/humupd/dmy007 https://researchmgt.monash.edu/ws/files/254864994/254656053_oa.pdf http://www.scopus.com/inward/record.url?scp=85051570807&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D6B72B5D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/humupd/dmy007 |
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