Academic Journal
Vimentin participates in microglia activation and neurotoxicity in cerebral ischemia
| العنوان: | Vimentin participates in microglia activation and neurotoxicity in cerebral ischemia |
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| المؤلفون: | Jiang, Susan X., Slinn, Jacqueline, Aylsworth, Amy, Hou, Sheng T. |
| المصدر: | Journal of Neurochemistry ; volume 122, issue 4, page 764-774 ; ISSN 0022-3042 1471-4159 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2012 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | J. Neurochem. (2012) 122 , 764–774. Abstract Microglia are the ‘immune cells’ of the brain and their activation plays a vital role in the pathogenesis of many neurodegenerative diseases. Activated microglia produce high levels of pro‐inflammatory factors, such as TNFα, causing neurotoxicity. Here we show that vimentin played a key role in controlling microglia activation and neurotoxicity during cerebral ischemia. Deletion of vimentin expression significantly impaired microglia activation in response to LPS in vitro and transient focal cerebral ischemia in vivo . Reintroduction of the functional vimentin gene back into vimentin knockout microglia restored their response to LPS. More importantly, impairment of microglia activation significantly protected brain from cerebral ischemia‐induced neurotoxicity. Collectively, we demonstrate a previously unknown function of vimentin in controlling microglia activation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1471-4159.2012.07823.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1471-4159.2012.07823.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-4159.2012.07823.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.2012.07823.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.D6B1FAEF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1471-4159.2012.07823.x |
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