التفاصيل البيبلوغرافية
| العنوان: |
Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. |
| المؤلفون: |
Hotta, Kikuko, Kitamoto, Takuya, Kitamoto, Aya, Mizusawa, Seiho, Matsuo, Tomoaki, Nakata, Yoshio, Kamohara, Seika, Miyatake, Nobuyuki, Kotani, Kazuaki, Komatsu, Ryoya, Itoh, Naoto, Mineo, Ikuo, Wada, Jun, Yoneda, Masato, Nakajima, Atsushi, Funahashi, Tohru, Miyazaki, Shigeru, Tokunaga, Katsuto, Masuzaki, Hiroaki, Ueno, Takato, Hamaguchi, Kazuyuki, Tanaka, Kiyoji, Yamada, Kentaro, Hanafusa, Toshiaki, Oikawa, Shinichi, Yoshimatsu, Hironobu, Sakata, Toshiie, Matsuzawa, Yuji, Nakao, Kazuwa, Sekine, Akihiro |
| المساهمون: |
堀田, 紀久子, 40523791 |
| بيانات النشر: |
Nature Publishing Group |
| سنة النشر: |
2011 |
| المجموعة: |
Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| مصطلحات موضوعية: |
FTO, metabolic syndrome, MTMR9, SCG3, Adult, Aged, Asian Continental Ancestry Group/genetics, Body Mass Index, Case-Control Studies, Chromogranins/genetics, Diabetes Mellitus/genetics, Dyslipidemias/genetics, Female, Genetic Predisposition to Disease/genetics, Humans, Hypertension/genetics, Male, Metabolic Syndrome X/genetics, Middle Aged, Obesity/genetics, Polymorphism, Single Nucleotide/genetics, Protein Tyrosine Phosphatases, Non-Receptor/genetics, Proteins/genetics |
| الوصف: |
Metabolic syndrome is defined as a cluster of multiple risk factors, including central obesity, dyslipidemia, hypertension and impaired glucose tolerance, that increase cardiovascular disease morbidity and mortality. Genetic factors are important in the development of metabolic syndrome, as are environmental factors. However, the genetic background of metabolic syndrome is not yet fully clarified. There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1. To investigate the relationship between metabolic syndrome and variations in these genes in the Japanese population, we genotyped 33 single-nucleotide polymorphisms (SNPs) in 19 genes from 1096 patients with metabolic syndrome and 581 control individuals who had no risk factors for metabolic syndrome. Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P=0.00013), rs8050136 (P=0.00011), rs1558902 (P=6.6 × 10(-5)) and rs1421085 (P=7.4 × 10(-5)). rs3764220 in the SCG3 gene (P=0.0010) and rs2293855 in the MTMR9 gene (P=0.0015) were also significantly associated with metabolic syndrome. SNPs in the FTO, SCG3 and MTMR9 genes had no SNP × SNP epistatic effects on metabolic syndrome. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
1434-5161 |
| Relation: |
http://hdl.handle.net/2433/157235; AA11206160; Journal of human genetics; 56; 647; 651 |
| الاتاحة: |
http://hdl.handle.net/2433/157235 |
| Rights: |
© 2011 The Japan Society of Human Genetics ; This is not the published version. Please cite only the published version. ; この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| رقم الانضمام: |
edsbas.D6899F0 |
| قاعدة البيانات: |
BASE |
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