Academic Journal
Journal of Natural Products / Labdane-type diterpenes from the aerial parts of Rydingia persica: their absolute configurations and protective effects on LPS-induced inflammation in keratinocytes
| العنوان: | Journal of Natural Products / Labdane-type diterpenes from the aerial parts of Rydingia persica: their absolute configurations and protective effects on LPS-induced inflammation in keratinocytes |
|---|---|
| المؤلفون: | Alilou, M., Marzocco, S., Hofer, D., Rapa, S.F., Asadpour, R., Schwaiger, S., Troppmair, J., Stuppner, H. |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2020 |
| المجموعة: | University of Innsbruck: Digital Library (Universitäts- und Landesbibliothek Tirol) |
| مصطلحات موضوعية: | peptides and proteins, carbon, circular dichroism spectroscopy, absolute configuration, inflammation |
| جغرافية الموضوع: | UI:CP:AP, UI:AE:MC |
| الوصف: | Phytochemical investigations of an extract of the aerial parts of Rydingia persica led to the isolation of 14 labdane-type diterpenoids, of which compounds 1-5, 8, and 12-14 turned out to be new natural products, while the remaining compounds were isolated for the first time from the genus Rydingia. Their structures were elucidated using 1D- and 2D-NMR and mass spectrometry, and their absolute configurations were determined by quantum chemical calculation methods. Furthermore, DP4+ NMR chemical shift probability calculations were performed for compounds 12-14, in order to elucidate the orientation of the ambiguous chiral center at C-15, prior to absolute configuration determination. The methanol extract of the aerial parts of R. persica along with subfractions obtained and selected isolated compounds were evaluated for their effects on inflammation-related factors such as nitrotyrosine formation, IL-6 release, and TNF-α[alpha] release, along with tight-junction proteins claudin-1 and occludin expression in LPS-stimulated HaCaT cells. Occludin and claudin-1 are tight-junction proteins, which play a pivotal role in wound repair mechanisms. Overall, the subfractions and compounds isolated showed moderate to high activity, indicating that labdane-type diterpenoids contribute to the anti-inflammatory and wound-healing activity of R. persica. ; Version of record |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1520-6025 |
| Relation: | vignette : https://diglib.uibk.ac.at/titlepage/urn/urn:nbn:at:at-ubi:3-15225/128; urn:nbn:at:at-ubi:3-15225; https://resolver.obvsg.at/urn:nbn:at:at-ubi:3-15225; local:99145888274503331; system:AC16154964 |
| DOI: | 10.1021/acs.jnatprod.0c00360 |
| الاتاحة: | https://doi.org/10.1021/acs.jnatprod.0c00360 https://diglib.uibk.ac.at/doi/10.1021/acs.jnatprod.0c00360 https://resolver.obvsg.at/urn:nbn:at:at-ubi:3-15225 |
| Rights: | cc-by_4 |
| رقم الانضمام: | edsbas.D65CB7D9 |
| قاعدة البيانات: | BASE |
| تدمد: | 15206025 |
|---|---|
| DOI: | 10.1021/acs.jnatprod.0c00360 |