Enhancing laboratory capacity during Ebola virus disease (EVD) heightened surveillance in Liberia: lessons learned and recommendations
| العنوان: | Enhancing laboratory capacity during Ebola virus disease (EVD) heightened surveillance in Liberia: lessons learned and recommendations |
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| المؤلفون: | Katawera, Victoria, Kohar, Henry, Mahmoud, Nuha, Raftery, Philomena, Wasunna, Christine Formarly Academic Consortium Combating Ebola in Liberia, Monrovia, Humrighouse, Ben Centers for Disease Control and Prevention , Atlanta, GA, Hardy, Patrick Ministry of Health, Monrovia, Saindon, John Centers for Disease Control and Prevention , Atlanta, GA, Schoepp, Randal United States Army Medical Research Inst. of Infectious Diseases, Fort Detrick, MD, Makvandi, Monear Sandia National Lab. , Albuquerque, NM, Hensley, Lisa National Institutes of Health , Bethesda, MD, Condell, Orla World Health Organization, Monrovia, Durski, Kara World Health Organization, Geneva, Singaravelu, Shalini World Health Organization, Geneva, Gahimbare, Laetitia World Health Organization, Monrovia, Olinger, Gene National Institutes of Health , Bethesda, MD, Kateh, Francis Ministry of Health, Monrovia, Naidoo, Dhamari World Health Organization, Geneva, Nsubuga, Peter Global Public Health Solutions, Atlanta, GA, Formenty, Pierre World Health Organization, Geneva, Nyenswah, Tolbert Ministry of Health, Monrovia, Oumer, Sheick World Health Organization, Brazzaville . Regional Office for Africa, Okeibunor, Joseph Chukwudi World Health Organization, Brazzaville . Regional Office for Africa, Talisuna, Ambrose World Health Organization, Brazzaville . Regional Office for Africa, Yahaya, Ali Ahmed World Health Organization, Brazzaville . Regional Office for Africa, Rajatonirina, Soatiana World Health Organization, Brazzaville . Regional Office for Africa, Williams, Desmond Centers for Disease Control and Prevention , Atlanta, GA, Dahn, Bernice Ministry of Health, Monrovia, Gasasira, Alex World Health Organization, Monrovia, Fall, Ibrahima Socé World Health Organization, Brazzaville . Regional Office for Africa |
| سنة النشر: | 2023 |
| المجموعة: | SciTec Connect (Office of Scientific and Technical Information - OSTI, U.S. Department of Energy) |
| مصطلحات موضوعية: | 60 APPLIED LIFE SCIENCES |
| الوصف: | Following a declaration by the World Health Organization that Liberia had successfully interrupted Ebola virus transmission on May 9th, 2015; the country entered a period of enhanced surveillance. The number of cases had significantly reduced prior to the declaration, leading to closure of eight out of eleven Ebola testing laboratories. Enhanced surveillance led to an abrupt increase in demand for laboratory services. We report interventions, achievements, lessons learned and recommendations drawn from enhancing laboratory capacity. Using archived data, we reported before and after interventions that aimed at increasing laboratory capacity. Laboratory capacity was defined by number of laboratories with Ebola Virus Disease (EVD) testing capacity, number of competent staff, number of specimens tested, specimen backlog, daily and surge testing capacity, and turnaround time. Using Stata 14 (Stata Corporation, College Station, TX, USA), medians and trends were reported for all continuous variables. Our results show that between May and December 2015, interventions including recruitment and training of eight staff, establishment of one EVD laboratory facility, implementation of ten Ebola GeneXpert diagnostic platforms, and establishment of working shifts yielded an 8-fold increase in number of specimens tested, a reduction in specimens backlog to zero, and restoration of turn-around time to 24 hours. This enabled a more efficient surveillance system that facilitated timely detection and containment of two EVD clusters observed thereafter. In conclusion, effective enhancement of laboratory services during high demand periods requires a combination of context-specific interventions. Building and ensuring sustainability of local capacity is an integral part of effective surveillance and disease outbreak response efforts. |
| نوع الوثيقة: | other/unknown material |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | http://www.osti.gov/servlets/purl/1629055; https://www.osti.gov/biblio/1629055; https://doi.org/10.11604/pamj.supp.2019.33.2.17366 |
| DOI: | 10.11604/pamj.supp.2019.33.2.17366 |
| الاتاحة: | http://www.osti.gov/servlets/purl/1629055 https://www.osti.gov/biblio/1629055 https://doi.org/10.11604/pamj.supp.2019.33.2.17366 |
| رقم الانضمام: | edsbas.D64122FC |
| قاعدة البيانات: | BASE |
| DOI: | 10.11604/pamj.supp.2019.33.2.17366 |
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