Academic Journal
Prognostic Relevance of Transforming Growth Factor-β Receptor Expression and Signaling in Glioblastoma, Isocitrate Dehydrogenase-Wildtype
| العنوان: | Prognostic Relevance of Transforming Growth Factor-β Receptor Expression and Signaling in Glioblastoma, Isocitrate Dehydrogenase-Wildtype |
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| المؤلفون: | Togni, Claudio, Rom, Emanuel, Burghardt, Isabel, Roth, Patrick, Rushing, Elisabeth J, Weller, Michael, Gramatzki, Dorothee |
| المصدر: | Togni, Claudio; Rom, Emanuel; Burghardt, Isabel; Roth, Patrick; Rushing, Elisabeth J; Weller, Michael; Gramatzki, Dorothee (2022). Prognostic Relevance of Transforming Growth Factor-β Receptor Expression and Signaling in Glioblastoma, Isocitrate Dehydrogenase-Wildtype. Journal of Neuropathology and Experimental Neurology, 81(3):225-235. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2022 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Clinic for Neurology, 610 Medicine & health |
| الوصف: | The transforming growth factor (TGF)-β signaling pathway has been recognized as a major factor in promoting the aggressive behavior of glioblastoma, isocitrate dehydrogenase-wildtype. However, there is little knowledge about the expression of TGF-β receptors in glioblastoma. Here, we studied the expression patterns of TGF-β receptor II (TGFβRII), type I receptors activin receptor-like kinase (ALK)-5, and ALK-1, as well as of the transcriptional regulators inhibitor of differentiation (Id) 2, Id3, and Id4 in human glioblastoma. The expression of TGFβRII, ALK-5, and ALK-1 varied greatly, with TGFβRII and ALK-5 being the most abundant and ALK-1 being the least expressed receptor. None of the 3 receptors was preferentially expressed by tumor vasculature as opposed to the tumor bulk, indicating tumor bulk-governed mechanisms of TGF-β signaling with regard to glioblastoma-associated angiogenesis. A positive correlation was found between ALK-1 and Id2, suggesting that Id2, broadly expressed in the tumor cells, is a downstream target of this receptor-dependent pathway. Furthermore, there was a trend for high expression of ALK-5 or Id2 to be associated with inferior overall survival. Hence, we propose that ALK-5 may be used for patient stratification in future anti-TGF-β treatment trials and that Id2 might be a potential target for anti-TGF-β interventions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-3069 |
| Relation: | https://www.zora.uzh.ch/218460; info:pmid/35190826; urn:issn:0022-3069 |
| DOI: | 10.1093/jnen/nlac007 |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/218460/ https://www.zora.uzh.ch/218460 https://doi.org/10.1093/jnen/nlac007 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.D5CAC8BF |
| قاعدة البيانات: | BASE |
| تدمد: | 00223069 |
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| DOI: | 10.1093/jnen/nlac007 |