Academic Journal
A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
| العنوان: | A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats |
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| المؤلفون: | Engelke, D. S., Zhang, X. O., O’Malley, J. J., Fernandez-Leon, J. A., Li, S., Kirouac, G. J., Beierlein, M., Do-Monte, F. H. |
| المصدر: | Nature Communications ; volume 12, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| الوصف: | Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Inactivation of aPVT CRF neurons during conflict biases animal’s response toward food, whereas activation of these cells recapitulates the food-seeking suppression observed during conflict. aPVT CRF neurons project densely to the nucleus accumbens (NAc), and activity in this pathway reduces food seeking and increases avoidance. In addition, we identified the ventromedial hypothalamus (VMH) as a critical input to aPVT CRF neurons, and demonstrated that VMH-aPVT neurons mediate defensive behaviors exclusively during conflict. Together, our findings describe a hypothalamic-thalamostriatal circuit that suppresses reward-seeking behavior under the competing demands of avoiding threats. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-021-22730-y |
| الاتاحة: | http://dx.doi.org/10.1038/s41467-021-22730-y https://www.nature.com/articles/s41467-021-22730-y.pdf https://www.nature.com/articles/s41467-021-22730-y |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.D5B870BF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-021-22730-y |
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