التفاصيل البيبلوغرافية
| العنوان: |
Fluoxetine effects on mitochondrial ultrastructure of right ventricle in rats exposed to cold stress |
| المؤلفون: |
Daud,Fernanda V., Murad,Neif, Meneghini,Adriano, Ferreira,Marcelo, Ferreira Filho,Celso, Abreu,Luiz Carlos de, Valenti,Vitor Engrácia, Ferreira,Celso |
| المصدر: |
Revista Brasileira de Cirurgia Cardiovascular v.24 n.2 2009 |
| بيانات النشر: |
Sociedade Brasileira de Cirurgia Cardiovascular |
| سنة النشر: |
2009 |
| المجموعة: |
SciELO Brazil (Scientific Electronic Library Online) |
| مصطلحات موضوعية: |
Fluoxetine, Surgery, Myocytes, cardiac, Cold ischemia |
| الوصف: |
OBJECTIVE: To assess fluoxetine effects on mitochondrial structure of the right ventricle in rats exposed to cold stress. METHODS: The experimental study procedures were performed in 250-300g male EPM-Wistar rats. Rats (n=40) were divided into four groups: 1) Control group (CON); 2) Fluoxetine (FLU); 3) Induced hypothermia (IH) and; 4) Induced hypothermia treated with fluoxetine (IHF). Animals of FLU group were treated by the administration of gavages containing 0.75 mg/kg/day fluoxetine during 40 days. The induced hypothermia was obtained by maintaining the groups 3 and 4 in a freezer at -8ºC for 4 hours. The animals were sacrificed and fragments of the right ventricle (RV) were removed and processed prior to performing electron microscopic analysis. RESULTS: The ultrastructural changes in cardiomyocytes were quantified through the number of mitochondrial cristae pattern (cristolysis). The CON (3.85%), FLU (4.47%) and IHF (8.4%) groups showed a normal cellular structure aspect with preserved cardiomyocytes cytoarchitecture and continuous sarcoplasmic membrane integrity. On the other hand, the IH (34.4%) group showed mitochondrial edema and lysis in cristae. CONCLUSION: The ultrastructural analysis revealed that fluoxetine strongly prevents mitochondrial cristolysis in rat heart, suggesting a protector effect under cold stress condition. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
text/html |
| اللغة: |
English |
| الاتاحة: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382009000200013 |
| رقم الانضمام: |
edsbas.D5A4AB11 |
| قاعدة البيانات: |
BASE |