Academic Journal
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
| العنوان: | RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement |
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| المؤلفون: | Lau, Christina M., Broughton, Courtney, Tabor, Abigail S., Akira, Shizuo, Flavell, Richard A., Mamula, Mark J., Christensen, Sean R., Shlomchik, Mark J., Viglianti, Gregory A., Rifkin, Ian R., Marshak-Rothstein, Ann |
| المصدر: | The Journal of Experimental Medicine ; volume 202, issue 9, page 1171-1177 ; ISSN 1540-9538 0022-1007 |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2005 |
| الوصف: | Previous studies (Leadbetter, E.A., I.R. Rifkin, A.H. Hohlbaum, B. Beaudette, M.J. Shlomchik, and A. Marshak-Rothstein. 2002. Nature. 416:603–607; Viglianti, G.A., C.M. Lau, T.M. Hanley, B.A. Miko, M.J. Shlomchik, and A. Marshak-Rothstein. 2003. Immunity. 19:837–847) established the unique capacity of DNA and DNA-associated autoantigens to activate autoreactive B cells via sequential engagement of the B cell antigen receptor (BCR) and Toll-like receptor (TLR) 9. We demonstrate that this two-receptor paradigm can be extended to the BCR/TLR7 activation of autoreactive B cells by RNA and RNA-associated autoantigens. These data implicate TLR recognition of endogenous ligands in the response to both DNA- and RNA-associated autoantigens. Importantly, the response to RNA-associated autoantigens was markedly enhanced by IFN-α, a cytokine strongly linked to disease progression in patients with systemic lupus erythematosus (SLE). As further evidence that TLRs play a key role in autoantibody responses in SLE, we found that autoimmune-prone mice, lacking the TLR adaptor protein MyD88, had markedly reduced chromatin, Sm, and rheumatoid factor autoantibody titers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1084/jem.20050630 |
| الاتاحة: | http://dx.doi.org/10.1084/jem.20050630 https://rupress.org/jem/article-pdf/202/9/1171/1719218/jem20291171.pdf |
| رقم الانضمام: | edsbas.D57D068B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20050630 |
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