Academic Journal
Pulmonary carcinogenicity of 3,9- and 3,7-dinitrofluoranthene, 3-nitrofluoranthene and benzo[a]pyrene in F344 rats
| العنوان: | Pulmonary carcinogenicity of 3,9- and 3,7-dinitrofluoranthene, 3-nitrofluoranthene and benzo[a]pyrene in F344 rats |
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| المؤلفون: | Horikawa, Kazumi, Sera, Nobuyuki, Otofuji, Takeshi, Murakami, Koichi, Tokiwa, Hiroshi, Iwagawa, Masanori, Izumi, Keisuke, Otsuka, Hisashi |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1991 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | ORIGINAL ARTICLES |
| الوصف: | 3,9- and 3,7-Dinitrofluoranthene (3,9- and 3,7-DNF), 3-nitrofluoranthene (3-NF) and benzo[a]pyrene (B[a]P) were tested for pulmonary carcinogenicity by intrapulmonary implantation of the compounds into rat lung. These chemicals were given in various doses as suspensions in beeswax–trycaprylin and the animals were observed for 100 weeks. The control group received no drugs. The incidences of lung tumors were 19/21 (90.5%), 7/10 (70%) and 1/10 (10%) in rats treated with 200, 100 and 50 μg of 3,9–DNF, 4/9 (44.4%), 3/10 (30%) and 0/10 (0%) in rats treated with 200, 100 and 50 μg of B[a]P, 12/22 (54.5%) in rats treated with 200 μg of 3,7-DNF and 1/20 (5%) in rats treated with 1000 μg of 3-NF respectively. No lung tumors were found in control rats. The incidence of lung tumors induced by 3,9-DNF was twice as high as that induced by B[a]P, when the equivalent dose levels of the two compounds were compared. Histologically, most of the tumors induced by 3,9- and 3,7-DNF and B[a]P were squamous cell carcinomas. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://carcin.oxfordjournals.org/cgi/content/short/12/6/1003; http://dx.doi.org/10.1093/carcin/12.6.1003 |
| DOI: | 10.1093/carcin/12.6.1003 |
| الاتاحة: | http://carcin.oxfordjournals.org/cgi/content/short/12/6/1003 https://doi.org/10.1093/carcin/12.6.1003 |
| Rights: | Copyright (C) 1991, Oxford University Press |
| رقم الانضمام: | edsbas.D56EB8F9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/carcin/12.6.1003 |
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