Academic Journal
State-of-the-art Review on the Antiparasitic Activity of Benzimidazolebased Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis
| العنوان: | State-of-the-art Review on the Antiparasitic Activity of Benzimidazolebased Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis |
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| المؤلفون: | Francesconi, Valeria, Rizzo, Marco, Schenone, Silvia, Carbone, Anna, Tonelli, Michele |
| المصدر: | Current Medicinal Chemistry ; volume 31, issue 15, page 1955-1982 ; ISSN 0929-8673 |
| بيانات النشر: | Bentham Science Publishers Ltd. |
| سنة النشر: | 2024 |
| الوصف: | Protozoan parasites represent a significant risk for public health worldwide, afflicting particularly people in more vulnerable categories and cause large morbidity and heavy economic impact. Traditional drugs are limited by their toxicity, low efficacy, route of administration, and cost, reflecting their low priority in global health management. Moreover, the drug resistance phenomenon threatens the positive therapy outcome. This scenario claims the need of addressing more adequate therapies. Among the diverse strategies implemented, the medicinal chemistry efforts have also focused their attention on the benzimidazole nucleus as a promising pharmacophore for the generation of new drug candidates. Hence, the present review provides a global insight into recent progress in benzimidazole-based derivatives drug discovery against important protozoan diseases, such as malaria, leishmaniasis and trypanosomiasis. The more relevant chemical features and structure-activity relationship studies of these molecules are discussed for the purpose of paving the way towards the development of more viable drugs for the treatment of these parasitic infections. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2174/0929867331666230915093928 |
| الاتاحة: | http://dx.doi.org/10.2174/0929867331666230915093928 https://www.eurekaselect.com/article/download?doi=10.2174/0929867331666230915093928 https://www.eurekaselect.com/221110/article |
| Rights: | https://creativecommons.org/licenses/by/4.0/legalcode |
| رقم الانضمام: | edsbas.D55B4F21 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/0929867331666230915093928 |
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