Academic Journal
Is Cytoreductive Nephrectomy Still a Standard of Care in Metastatic Renal Cell Carcinoma?
| العنوان: | Is Cytoreductive Nephrectomy Still a Standard of Care in Metastatic Renal Cell Carcinoma? |
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| المؤلفون: | Renner, Alex, Samtani, Suraj, Marín, Arnaldo, Burotto, Mauricio |
| المصدر: | Journal of Kidney Cancer and VHL; Vol. 6 No. 1 (2019): Journal of Kidney Cancer and VHL; 1-7 ; 2203-5826 |
| بيانات النشر: | Codon Publications |
| سنة النشر: | 2019 |
| المجموعة: | Journal of Kidney Cancer and VHL (JKCVHL) |
| مصطلحات موضوعية: | cytoreductive nephrectomy, immunotherapy, metastatic renal cell carcinoma, sunitinib, surgical outlook, Kidney Cancer, Oncology |
| الوصف: | Cytoreductive nephrectomy has been an integral part of management in metastatic renal cell carcinoma for patients with good performance status, based on the benefit shown by prospective trials in the interferon era and retrospective trials in the targeted therapies era. Clinical Trial to Assess the Importance of Nephrectomy (CARMENA), the first prospective phase III trial comparing a targeted agent alone (sunitinib) versus nephrectomy plus sunitinib, has been recently published, showing non-inferiority for the nephrectomy-sparing arm. In this article, we discuss the impact of nephrectomy including its immune-mediated effects, surgical morbidity and mortality, and the clinical data supporting the indications of nephrectomy in order to analyze the CARMENA trial in context, with the aim to identify optimal strategies for different patient populations in the metastatic setting. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/html; application/xml |
| اللغة: | English |
| Relation: | https://jkcvhl.com/index.php/jkcvhl/article/view/114/232; https://jkcvhl.com/index.php/jkcvhl/article/view/114/233; https://jkcvhl.com/index.php/jkcvhl/article/view/114/234; https://jkcvhl.com/index.php/jkcvhl/article/view/114 |
| DOI: | 10.15586/jkcvhl.2019.114 |
| الاتاحة: | https://jkcvhl.com/index.php/jkcvhl/article/view/114 https://doi.org/10.15586/jkcvhl.2019.114 |
| Rights: | Copyright (c) 2019 Suraj Samtani ; https://creativecommons.org/licenses/by-nc-nd/4.0 |
| رقم الانضمام: | edsbas.D54B006E |
| قاعدة البيانات: | BASE |
| DOI: | 10.15586/jkcvhl.2019.114 |
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