Academic Journal
Therapeutic application of extracellular vesicles in acute and chronic renal injury
| العنوان: | Therapeutic application of extracellular vesicles in acute and chronic renal injury |
|---|---|
| المؤلفون: | Jordi Rovira, Fritz Diekmann, Josep M. Campistol, María José Ramírez-Bajo |
| المصدر: | Nefrología (English Edition), Vol 37, Iss 2, Pp 126-137 (2017) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Extracellular vesicles, Acute and chronic renal injury, Regenerative therapy, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | A new cell-to-cell communication system was discovered in the 1990s, which involves the release of vesicles into the extracellular space. These vesicles shuttle bioactive particles, including proteins, mRNA, miRNA, metabolites, etc. This particular communication has been conserved throughout evolution, which explains why most cell types are capable of producing vesicles. Extracellular vesicles (EVs) are involved in the regulation of different physiological processes, as well as in the development and progression of several diseases. EVs have been widely studied over recent years, especially those produced by embryonic and adult stem cells, blood cells, immune system and nervous system cells, as well as tumour cells. EV analysis from bodily fluids has been used as a diagnostic tool for cancer and recently for different renal diseases. However, this review analyses the importance of EVs generated by stem cells, their function and possible clinical application in renal diseases and kidney transplantation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2013-2514 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2013251417300706; https://doaj.org/toc/2013-2514; https://doaj.org/article/ac62545ecfa14dc28070572cf8bc4511 |
| DOI: | 10.1016/j.nefroe.2017.03.004 |
| الاتاحة: | https://doi.org/10.1016/j.nefroe.2017.03.004 https://doaj.org/article/ac62545ecfa14dc28070572cf8bc4511 |
| رقم الانضمام: | edsbas.D5333B45 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20132514 |
|---|---|
| DOI: | 10.1016/j.nefroe.2017.03.004 |