Academic Journal
Increased levels of intramuscular cytokines in patients with jaw muscle pain
| العنوان: | Increased levels of intramuscular cytokines in patients with jaw muscle pain |
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| المؤلفون: | Louca Jounger, S, Christidis, N, Svensson, P, List, T, Ernberg, M |
| المصدر: | Louca Jounger , S , Christidis , N , Svensson , P , List , T & Ernberg , M 2017 , ' Increased levels of intramuscular cytokines in patients with jaw muscle pain ' , Journal of Headache and Pain , vol. 18 , no. 1 , 30 . https://doi.org/10.1186/s10194-017-0737-y |
| سنة النشر: | 2017 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | Adult, Bruxism, Cytokines, Facial Pain, Female, Humans, Inflammation, Journal Article, Masseter Muscle, Microdialysis, Myalgia, Temporomandibular Joint Disorders |
| الوصف: | BACKGROUND: The aim of this study was to investigate cytokine levels in the masseter muscle, their response to experimental tooth-clenching and their relation to pain, fatigue and psychological distress in patients with temporomandibular disorders (TMD) myalgia. METHODS: Forty women, 20 with TMD myalgia (Diagnostic Criteria for TMD) and 20 age-matched healthy controls participated. Intramuscular microdialysis was performed to sample masseter muscle cytokines. After 140 min (baseline), a 20-minute tooth-clenching task was performed (50% of maximal voluntary contraction force). Pain (Numeric rating scale 0-10) and fatigue (Borg's Ratings of Perceived Exertion 6-20) were assessed throughout microdialysis, while pressure-pain thresholds (PPT) were assessed before and after microdialysis. Perceived stress (PSS-10) and Trait Anxiety (STAI) were assessed before microdialysis. RESULTS: The levels of IL-6, IL-7, IL-8 and IL-13 were higher in patients than controls (Mann Whitney U-test; P's < 0.05) during the entire microdialysis. IL-6, IL-8 and IL-13 changed during microdialysis in both groups (Friedman; P's < 0.05), while IL-1β, IL-7 and GM-CSF changed only in patients (P's < 0.01). IL-6 and IL-8 increased in response to tooth-clenching in both groups (Wilcoxon test; P's < 0.05), while IL-7, IL-13 and TNF increased only in patients (P's < 0.05). Patients had higher pain and fatigue than controls before and after tooth-clenching (P < 0.001), and lower PPTs before and after microdialysis (P < 0.05). There were no correlations between cytokine levels, pain or fatigue. Also, there were no differences in stress or anxiety levels between groups. CONCLUSIONS: In conclusion, the masseter levels of IL-6, IL-7, IL-8 and IL-13 were elevated in patients with TMD myalgia and increased in response to tooth-clenching. Tooth-clenching increased jaw muscle pain and fatigue, but without correlations to cytokine levels. This implies that subclinical muscle inflammation may be involved in TMD myalgia pathophysiology, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://pure.au.dk/portal/en/publications/21e6fac7-83c7-4c3b-b29c-77eaf5c417a8 |
| DOI: | 10.1186/s10194-017-0737-y |
| الاتاحة: | https://pure.au.dk/portal/en/publications/21e6fac7-83c7-4c3b-b29c-77eaf5c417a8 https://doi.org/10.1186/s10194-017-0737-y |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D4F6C95D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s10194-017-0737-y |
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