Academic Journal
Influence of BMI and geographical region on prescription of oral anticoagulants in newly diagnosed atrial fibrillation: The GLORIA-AF Registry Program
| العنوان: | Influence of BMI and geographical region on prescription of oral anticoagulants in newly diagnosed atrial fibrillation: The GLORIA-AF Registry Program |
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| المؤلفون: | Boriani, Giuseppe, Huisman, Menno V, Teutsch, Christine, Marler, Sabrina, Franca, Lionel Riou, Lu, Shihai, Lip, Gregory YH |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2020 |
| المجموعة: | The University of Liverpool Repository |
| الوصف: | Objective To investigate the association between body mass index (BMI) and oral anticoagulant (OAC) prescription in atrial fibrillation (AF). Methods Patients with newly diagnosed non-valvular AF (<3 months) with ≥1 stroke risk factors enrolled in the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) in Asia, Europe and North America were evaluated. Results The cohort (n = 13,793) comprised patients from all BMI categories (kg/m 2 ): 1.4% were underweight (<18.5), 27.3% had a normal BMI (18.5 to <25), 37.9% were overweight (25 to <30), 19.3% were moderately obese (30 to <35), and 12.7% were morbidly obese (≥35). The highest proportion of Asians had a BMI of 18.5 to <25 kg/m 2 , while the highest proportion of patients from Europe and North America were overweight and a substantial proportion of North Americans morbidly obese. In the multivariable analysis, the probability ratio of non-prescription of OAC, as compared to normal BMI, decreased for overweight (RR = 0.907), moderately obese (RR = 0.802) and severe very severe obese patients (RR = 0.659). Moreover, the probability ratio of non-prescription of OACs was increased in the Asia or North America regions, as compared with Europe, in patients aged <65 years or female patients, as well as in patients with prior bleeding or vascular disease. Conclusions The distribution of BMI differed among the continents. An increased BMI was associated with a lower probability of non-prescription of OACs, as compared with a normal BMI. The probability of non-prescription of OACs was increased in the Asia or North America regions, as compared with Europe. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | http://livrepository.liverpool.ac.uk/3105301/1/G%20Boriani%20-%20BMI%20in%20GLORIA%20AF%20-%20revised%203%20%20APR%202020%5B2%5D.docx; Boriani, Giuseppe, Huisman, Menno V, Teutsch, Christine, Marler, Sabrina, Franca, Lionel Riou, Lu, Shihai and Lip, Gregory YH orcid:0000-0002-7566-1626 (2020) Influence of BMI and geographical region on prescription of oral anticoagulants in newly diagnosed atrial fibrillation: The GLORIA-AF Registry Program. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 80. pp. 35-44. |
| DOI: | 10.1016/j.ejim.2020.04.032 |
| الاتاحة: | http://livrepository.liverpool.ac.uk/3105301/ https://doi.org/10.1016/j.ejim.2020.04.032 http://livrepository.liverpool.ac.uk/3105301/1/G%20Boriani%20-%20BMI%20in%20GLORIA%20AF%20-%20revised%203%20%20APR%202020%5B2%5D.docx |
| رقم الانضمام: | edsbas.D47B1D23 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejim.2020.04.032 |
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