Academic Journal
Validating Diagnostic and Screening Procedures for Pre-Motor Parkinson's Disease
| العنوان: | Validating Diagnostic and Screening Procedures for Pre-Motor Parkinson's Disease |
|---|---|
| المؤلفون: | Langston, J W, Goldman, Samuel M |
| المساهمون: | PARKINSONS INST SUNNYVALE CA |
| المصدر: | DTIC |
| سنة النشر: | 2013 |
| المجموعة: | Defense Technical Information Center: DTIC Technical Reports database |
| مصطلحات موضوعية: | Medicine and Medical Research, DIAGNOSIS(MEDICINE), MEDICAL SCREENING, PARKINSONS DISEASE, DISEASES, DYSFUNCTION, ELECTROCARDIOGRAPHY, HEART RATE, INFRASTRUCTURE, ORDER DISORDER TRANSFORMATIONS, PRE-MOTOR, PARKINSON'S DISEASE, LEWY BODY DISEASE, RBD(REM BEHAVIOR DISORDER), CARDIAC DYSAUTONOMIA, ELECTROCARDIOGRAM, HRV(HEART RATE VARIABILITY), DIAGNOSTIC SCREENING |
| الوصف: | The goal of this 24-month proposal is to establish the critical infrastructure for the initiation of a five year prospective follow-up study to identify those at risk for developing PD or a related Lewy body disorder in three study populations. The ultimate goal of this work is to develop low-cost non-invasive screening methods to detect pre-motor Parkinson s disease (PD) that can be implemented population-wide. Our hypothesis is that cardiac autonomic dysfunction assessed as heart rate variability (HRV) using a standard EKG, in combination with hyposmia and other simple screening tests, will be highly predictive of abnormalities in DAT imaging and ultimately predict the emergence of full-blown PD or a related Lewy body disorder. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://www.dtic.mil/docs/citations/ADA602970 |
| الاتاحة: | http://www.dtic.mil/docs/citations/ADA602970 http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA602970 |
| Rights: | Approved for public release; distribution is unlimited. |
| رقم الانضمام: | edsbas.D46D358D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |