Academic Journal
Gut microbiota composition and arterial stiffness measured by pulse wave velocity: Case-control study protocol (MIVAS study)
| العنوان: | Gut microbiota composition and arterial stiffness measured by pulse wave velocity: Case-control study protocol (MIVAS study) |
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| المؤلفون: | Salvado, Rita, Santos-Mínguez, Sandra, Agudo-Conde, Cristina, Lugones-Sánchez, Cristina, Cabo-Laso, Ángela, Hernandez-Sánchez, Jesus M., Benito, Rocío, Rodriguez-Sanchez, Emiliano, Gomez-Marcos, Manuel A., Hernández, Jesús M., Guimarães Cunha, Pedro, García-Ortiz, Luis |
| المساهمون: | Instituto de Salud Carlos III, European Commission, Junta de Castilla y León |
| بيانات النشر: | BMJ Publishing Group |
| سنة النشر: | 2021 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| الوصف: | [Introduction]: Intestinal microbiota is arising as a new element in the physiopathology of cardiovascular diseases. A healthy microbiota includes a balanced representation of bacteria with health promotion functions (symbiotes). The aim of this study is to analyse the relationship between intestinal microbiota composition and arterial stiffness. [Methods and analysis]: An observational case—control study will be developed. Cases will be defined by the presence of at least one of the following: carotid-femoral pulse wave velocity (cf-PWV), Cardio-Ankle Vascular Index (CAVI), brachial ankle pulse wave velocity (ba or ba-PWV) above the 90th percentile, for age and sex, of the reference population. Controls will be selected from the same population as cases. The study will be developed in Primary Healthcare Centres. We will select 500 subjects (250 cases and 250 controls), between 45 and 74 years of age. Cases will be selected from a database that combines data from EVA study (Spain) and Guimarães/Vizela study (Portugal). Measurements: cf-PWV will be measured using the SphygmoCor system, CAVI, ba-PWV and Ankle-Brachial Index will be determined using VaSera device. Gut microbiome composition in faecal samples will be determined by 16S ribosomal RNA sequencing. Lifestyle will be assessed by food frequency questionnaire, adherence to the Mediterranean diet and IPAQ (International Physical Activity Questionnaire). Body composition will be evaluated by bioimpedance. [Ethics and dissemination]: The study has been approved by ‘Committee of ethics of research with medicines of the health area of Salamanca’ on 14 December 2018 (cod. 2018-11-136) and the ’Ethics committee for health of Guimaraes’ (Portugal) on 15 October 2019 (ref: 67/2019).All study participants will sign an informed consent form agreeing to participate in the study, in compliance with the Declaration of Helsinki and the WHO standards for observational studies. The results of this study will allow a better description of gut microbiota in patients with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 2044-6055 |
| Relation: | Publisher's version; http://dx.doi.org/10.1136/bmjopen-2020-038933; Sí; BMJ Open 11: e038933 (2021); http://hdl.handle.net/10261/268000; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/501100004587; http://dx.doi.org/10.13039/501100014180 |
| DOI: | 10.1136/bmjopen-2020-038933 |
| DOI: | 10.13039/501100000780 |
| DOI: | 10.13039/501100004587 |
| DOI: | 10.13039/501100014180 |
| الاتاحة: | http://hdl.handle.net/10261/268000 https://doi.org/10.1136/bmjopen-2020-038933 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100004587 https://doi.org/10.13039/501100014180 |
| Rights: | open |
| رقم الانضمام: | edsbas.D444C09A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20446055 |
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| DOI: | 10.1136/bmjopen-2020-038933 |