Academic Journal
Novel Optical Biosensor Based on a Nano-Gold Coated by Schiff Base Doped in Sol/Gel Matrix for Sensitive Screening of Oncomarker CA-125
| العنوان: | Novel Optical Biosensor Based on a Nano-Gold Coated by Schiff Base Doped in Sol/Gel Matrix for Sensitive Screening of Oncomarker CA-125 |
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| المؤلفون: | Mohamed, Ekram Hany, Attia, Mohamed S. S., Abou-Omar,, Mona N, Amin,, Mohammed A., Boukherroub, Rabah, afify, hisham |
| المصدر: | Pharmacy |
| بيانات النشر: | BUE Scholar |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Laboratory and Basic Science Research |
| الوصف: | The urge for sensitive, facile, minimally invasive, and fast detection method of CA-125, a significant and crucial biomarker in ovarian malignancy, is currently substantial. This paper describes the detailed construction and characterization of a newly designed optical nano-biosensor to detect CA-125 accurately and sensitively. The fabricated sensor consists of a nano-gold thin film doped into a matrix of sol-gel, exhibiting a centered fluorescence band at 423 nm when excited at 340 nm. The quantification of CA-125 relies on its quenching ability of this fluorescence signal. The sensor was challenged to evaluate its sensitivity and specificity in detecting CA-125 present in samples collected from ovarian cancer diagnosed patients and compared to samples from healthy women as a control. Our findings revealed that the developed biosensor had a sensitivity of 97.35% and a specificity of 94.29%. Additionally, a wide linearity range over 2.0-127.0 U mL-1 for CA-125 was achieved with a detection limit of 1.45 U mL-1. Furthermore, the sensor could successfully discriminate samples between healthy and diseased people, which demonstrates its suitability in CA-125 assessment. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://buescholar.bue.edu.eg/pharmacy/696; https://buescholar.bue.edu.eg/context/pharmacy/article/1722/viewcontent/omega.pdf |
| الاتاحة: | https://buescholar.bue.edu.eg/pharmacy/696 https://buescholar.bue.edu.eg/context/pharmacy/article/1722/viewcontent/omega.pdf |
| رقم الانضمام: | edsbas.D43E4A52 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |