Academic Journal
OP0063 QUANTITATIVE COMPUTED TOMOGRAPHY PREDICTS 10-YEAR MORTALITY IN INTERSTITIAL LUNG DISEASE RELATED TO SYSTEMIC SCLEROSIS
| العنوان: | OP0063 QUANTITATIVE COMPUTED TOMOGRAPHY PREDICTS 10-YEAR MORTALITY IN INTERSTITIAL LUNG DISEASE RELATED TO SYSTEMIC SCLEROSIS |
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| المؤلفون: | Ariani, A., Bravi, E., De Santis, M., Hax, V., Parisi, S., Lumetti, F., Girelli, F., Saracco, M., De Gennaro, F., Giollo, A., Abdel Jaber, M., Bozzao, F., Silva, M., Ditto, M. C., Lomater, C., Mozzani, F., Santilli, D., Di Donato, E., Becciolini, A., Pucciarini, F., Canziani, L., Bodini, F. C., Arrigoni, E., Bredemeier, M., Mendonça Da Silva Chakr, R., Spinella, A., Idolazzi, L., Bortolotti, R., Tomietto, P., Baratella, E., Tollot, S., Giuggioli, D., Fischetti, F., Fusaro, E., Sverzellati, N., Scirè, C. A. |
| المصدر: | Annals of the Rheumatic Diseases ; volume 79, issue Suppl 1, page 42.1-42 ; ISSN 0003-4967 1468-2060 |
| بيانات النشر: | BMJ |
| سنة النشر: | 2020 |
| الوصف: | Background: Interstitial lung disease (ILD) is the main cause of death in Systemic Sclerosis (SSc). Chest CT is the gold standard in detecting ILD although it is not easy to understand its prognostic value. ILD qualitative assessment is almost worthless. Goh et al. semi quantitative score of ILD extent is related to mortality risk but it is burdened by relevant inter/intra-readers variability. An operator independent algorithm based on voxel-wise analysis proved to identify SSc patients with an increased risk of mortality according to prediction models. Objectives: To verify if quantitative analysis of chest CT (QCT) predict 10 years-mortality in SSc patients. Methods: SSc patients with availability of a chest CT were enrolled in 13 different centers. The CT voxel-wise analysis with a free software ( www.horosproject.com ) provided QCT indexes: kurtosis, skewness, mean lung attenuation and standard deviation. Patients characteristics, autoimmune profile and pulmonary function test were collected. The follow-up interval lasted from the date of chest CT to the one of the last visit or death. Each QCT index cutoff, established in a previous study (1), clustered patients in two groups. Kaplan-Meier analysis estimated and compared survival in the above mentioned groups. p < 0.05 was considered statistically significant. Results: Five hundred sixty three SSc patients were enrolled (35938 patient-months); 52.4% had ILD detectable at CT scan. For each QCT index cutoff the cohort was split in two subgroups without differences in terms of sex, age, disease duration, autoimmune profile. All QCT indexes’ cutoff selected subgroups with statistically different survival rate (e.g in Figure 1). Figure 1 Conclusion: QCT can arise as the new gold standard in identifying SSc patients with poor prognosis. The real possibility to stratify SSc subjects according mortality risk will have a pivotal role in ILD treatment decisional process with the incoming anti-fibrotic drugs. References: [1]Ariani A et al. Rheumatology 2017 ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1136/annrheumdis-2020-eular.2239 |
| الاتاحة: | http://dx.doi.org/10.1136/annrheumdis-2020-eular.2239 https://syndication.highwire.org/content/doi/10.1136/annrheumdis-2020-eular.2239 |
| رقم الانضمام: | edsbas.D43163DE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/annrheumdis-2020-eular.2239 |
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