التفاصيل البيبلوغرافية
| العنوان: |
Original Article Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo |
| المؤلفون: |
Nozomu Matsunaga, Yuichi Chikaraishi, Masamitsu Shimazawa, Shigeru Yokota, Hideaki Hara |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b9/5c/Evid_Based_Complement_Alternat_Med_2010_Mar_27_7(1)_47-56.tar.gz |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
angiogenesis – VEGF – Bilberry (Vaccinium myrtillus) extraction – GM6001 – MMP – antioxidant – ERK 1 |
| الوصف: |
Vaccinium myrtillus (Bilberry) extracts (VME) were tested for effects on angiogenesis in vitro and in vivo. VME (0.3–30 mgml 1) and GM6001 (0.1–100 mM; a matrix metalloproteinase inhibitor) concentration-dependently inhibited both tube formation and migration of human umbilical vein endothelial cells (HUVECs) induced by vascular endothelial growth factor-A (VEGF-A). In addition, VME inhibited VEGF-A-induced proliferation of HUVECs. VME inhibited VEGF-A-induced phosphorylations of extracellular signal-regulated kinase 1/2 (ERK 1/2) and serine/threonine protein kinase family protein kinase B (Akt), but not that of phospholipase Cg (PLCg). In an in vivo assay, intravitreal administration of VME inhibited the formation of neovascular tufts during oxygen-induced retinopathy in mice. Thus, VME inhibited angiogenesis both in vitro and in vivo, presumably by inhibiting the phosphorylations of ERK 1/2 and Akt. These findings indicate that VME may be effective against retinal diseases involving angiogenesis, providing it can reach the retina after its administration. Further investigations will be needed to clarify the major angiogenesis-modulating constituent(s) of VME. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/zip |
| اللغة: |
English |
| Relation: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.357.478 |
| الاتاحة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.357.478 |
| Rights: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.D40F3BA8 |
| قاعدة البيانات: |
BASE |