Academic Journal
Influence of Thyroid Hormones and Transforming Growth Factor-β1 on Cystatin C Concentrations
| العنوان: | Influence of Thyroid Hormones and Transforming Growth Factor-β1 on Cystatin C Concentrations |
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| المؤلفون: | Kotajima, N, Yanagawa, Y, Aoki, T, Tsunekawa, K, Morimura, T, Ogiwara, T, Nara, M, Murakami, M |
| المصدر: | Journal of International Medical Research ; volume 38, issue 4, page 1365-1373 ; ISSN 0300-0605 1473-2300 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2010 |
| الوصف: | Serum cystatin C concentrations are reported to increase in the hyperthyroid state. Serum concentrations of cystatin C and transforming growth factor-β1 (TGF-β1) were measured in patients with thyroid dysfunction, and the effects of 3,5,3′-tri-iodothyronine (T 3 ) and TGF-β1 on cystatin C production in human hepatoblastoma (Hep G2) cells were studied. Serum concentrations of cystatin C and TGF-β1 were significantly higher in patients with Graves' disease compared with control subjects. Significantly positive correlations were observed between thyroid hormones and cystatin C, thyroid hormones and TGF-β1, and TGF-β1 and cystatin C in patients with thyroid dysfunction. Serum concentrations of cystatin C and TGF-β1 decreased after treatment for hyperthyroidism. Cystatin C mRNA levels and cystatin C secretion were increased by T 3 and TGF-β1 in cultured Hep G2 cells. These results suggest that serum cystatin C concentrations increase in patients with hyperthyroidism. The mechanisms for this may involve elevation of serum TGF-β1 levels and the stimulatory effects of T 3 and TGF-β1 on cystatin C production. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/147323001003800418 |
| الاتاحة: | https://doi.org/10.1177/147323001003800418 https://journals.sagepub.com/doi/pdf/10.1177/147323001003800418 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.D3B92DE6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/147323001003800418 |
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