Academic Journal
Adolescents With Breakthrough COVID-19 Infections Requiring Hospitalization: A Multicenter Retrospective Study
| العنوان: | Adolescents With Breakthrough COVID-19 Infections Requiring Hospitalization: A Multicenter Retrospective Study |
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| المؤلفون: | Okur, Dicle Åžener, Demirdag, Tugba, Cakici, Ozlem, Bal, Alkan, Ergun, Deniz, Altug, Umut, Arslan, Asli, Isancli, Didem Kizmaz, Torun, Selda Hancerli, Celik, Umit, Yasar, Belma, Erbas, Irem Ceren, Oncel, Eda Karadag, Akbas, Ali, Åžahbudak Bal, Zümrüt, Arslan, Sema Yıldırım, Güner Özenen, Gizem, Kılıçaslan, Önder, DemirbuÄŸa, Asuman, Turgut, Elif Afat, Dalgic, Nazan, Belet, Nursen, Inceli, Hatice Belkis, Elvan-Tuz, Aysegul, Kara, Tugce Tural, Bulbul, Beyhan, Gudeloglu, Elif, Sen, Semra, Kacar, Pelin, Dede, Elif, Petmezci, Ercument, Aksoy, Fatma Dilsad, Karbuz, Adem, Oncel, Selim, Tezer, Hasan, Devrim, Ilker, Ciftci, Ergin, Hacimustafaoglu, Mustafa, Kurugol, Zafer |
| بيانات النشر: | Springernature |
| سنة النشر: | 2024 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | hospitalization in covid-19, adolescent, covid-19, sars-cov-2, vaccine breakthrough infection, Sars-Cov-2 Infection |
| الوصف: | Background Vaccines have the most important role in the battle against the COVID-19 pandemic. With the widespread use of vaccines, COVID-19 has remarkably declined. Adolescents were vaccinated after approvals for this age group, which was later than adults, and a nationwide vaccination program was implemented in August 2021 in Turkey for adolescents >= 12 years of age. Therefore, we aimed to determine the effects of the COVID-19 nationwide adolescent vaccination program on adolescent hospitalizations due to COVID-19 and multisystem inflammatory syndrome in children (MIS-C) by comparing two periods, including the vaccination period (VP) and the pre-VP (PVP). The second aim of this study is to compare the clinical features and disease severity of vaccine-breakthrough COVID-19 hospitalizations with unvaccinated individuals in the VP. Methods A retrospective multicenter study was conducted to determine and compare the number of hospitalizations due to COVID-19 and MIS-C between the VP (September 1, 2021, to August 31, 2022) and PVP (September 1, 2020, to August 31, 2021). We also compared the characteristics, risk factors, and outcomes of breakthrough infections of adolescents aged 12-18, which required hospitalization with the same age group of unvaccinated hospitalized individuals during the VP. Results During the study period, 3967 children (0-18 years) were hospitalized in the PVP and 5143 (0-18 years) in the VP. Of them, 35.4% were adolescents (12-18 years) in the PVP, and this rate was 18.6% in the VP; relative risk was 0.6467 (95% confidence interval [CI]: 0.6058-0.6904; p 0.001). Patients with breakthrough COVID- 19 were older (201 vs. 175 months, p 0.001) and less commonly hospitalized for COVID-19 (81.5% vs. 60.4%, p 0.001, odds ratio [OR]: 0.347 [95% CI: 0.184-0.654]). The majority of these infections were asymptomatic and mild (32% vs.72.9%: p 0.001, OR: 5.718 [95% CI: 2.920-11.200]), and PICU admission was less frequently required (p = 0.011, OR: 0.188 [95% CI: 0.045-0.793]). Most breakthrough ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Cureus Journal of Medical Science; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.7759/cureus.60940; https://hdl.handle.net/11499/57560; 16; WOS:001250408900028 |
| DOI: | 10.7759/cureus.60940 |
| الاتاحة: | https://hdl.handle.net/11499/57560 https://doi.org/10.7759/cureus.60940 |
| Rights: | open |
| رقم الانضمام: | edsbas.D3AC9284 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7759/cureus.60940 |
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