التفاصيل البيبلوغرافية
| العنوان: |
No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial |
| المؤلفون: |
Gwendolyn N. Y. van Gorkom, Lara S. Boerenkamp, Birgit L. M. G. Gijsbers, Heidi H. van Ojik, Will K. W. H. Wodzig, Lotte Wieten, Catharina H. M. J. Van Elssen, Gerard M. J. Bos |
| المصدر: |
Nutrients; Volume 14; Issue 22; Pages: 4784 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
vitamin C, autologous hematopoietic stem cell transplantation, neutrophil |
| جغرافية الموضوع: |
agris |
| الوصف: |
Vitamin C is an important micronutrient for various immune cells. It increases phagocytic cell function and is necessary for T and natural killer (NK) cell development. Patients in need of an autologous hematopoietic stem cell transplantation (HSCT) are often vitamin C-depleted. We therefore hypothesized that vitamin C supplementation could improve immune recovery in autologous HSCT patients. This blinded, placebo-controlled trial included 44 patients randomized to receive vitamin C or a placebo. The following outcome measures used were clinical and immunological parameters, among others: time to neutrophil recovery, serum, and intracellular vitamin C values. Twenty-one patients received vitamin C, and 23 received a placebo. The time to neutrophil recovery did not differ between the two groups at 11.2 days (p = 0.96). There were no differences in hospitalization time (19.7 vs. 19.1 days, p = 0.80), the incidence of neutropenic fever (57% vs. 78%, p = 0.20), or 3-month overall survival (90.5% vs. 100%, p = 0.13). Bacteremia seemed to occur less in the vitamin C group (10% vs. 35%, p = 0.07). Our study shows no benefit from vitamin C supplementation on neutrophil recovery and hospitalization, despite possible lower rates of bacteremia in the vitamin C group. Therefore, we do not advise vitamin C supplementation in this treatment group. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Nutrition and Public Health; https://dx.doi.org/10.3390/nu14224784 |
| DOI: |
10.3390/nu14224784 |
| الاتاحة: |
https://doi.org/10.3390/nu14224784 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.D39D249 |
| قاعدة البيانات: |
BASE |