Academic Journal
Prognostic values of ADCmean and SUVmax of the primary tumour in cervical cancer patients treated with definitive chemoradiotherapy
| العنوان: | Prognostic values of ADCmean and SUVmax of the primary tumour in cervical cancer patients treated with definitive chemoradiotherapy |
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| المؤلفون: | Berna Akkus Yildirim, Cem Onal, Gurcan Erbay, Ozan Cem Guler, Elif Karadeli, Mehmet Reyhan, Zafer Koc |
| المصدر: | Journal of Obstetrics and Gynaecology, Vol 39, Iss 2, Pp 224-230 (2019) |
| بيانات النشر: | Taylor & Francis Group |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | cervical cancer, chemoradiotherapy, positron emission tomography, magnetic resonance imaging, prognostic factor, Gynecology and obstetrics, RG1-991 |
| الوصف: | We analysed the correlation of 18F-fluorodeoxyglucose uptake into primary tumours using the maximum standardised uptake value (SUVmax) and the mean apparent diffusion coefficient (ADCmean) values in magnetic resonance imaging (MRI) with the clinical and pathological factors in patients with cervical cancer who were treated with concurrent chemoradiotherapy. The patients were stratified according to the primary tumour pre-treatment ADCmean and SUVmax cut-off values. There were significant correlations between the SUVmax of the primary tumour and tumour size, and the treatment response. The correlation between the ADCmean and FIGO stage, tumour size, and the lymph node metastasis was significant. The SUVmax was significantly and inversely correlated with the ADCmean for cervical cancer (r = −0.44, p <.001). In the multivariate analysis, the primary tumour ADCmean, treatment response and the lymph node metastasis emerged as significant independent predictors of both OS and DFS, and of the primary tumour SUVmax for DFS. Tumour size has a borderline significance for OS. High SUVmax and low ADCmean of the primary tumour are important predictive factors for identifying high-risk patients with cervical cancer who are treated with definitive chemoradiotherapy. These results point to a future role for the diffusion-weighted MRI and for 18F-fluorodeoxyglucose positron emission tomography, not only in the staging of cervical cancer but as an aid in the selection of an adjuvant treatment regimen after chemoradiotherapy for individual patients.Impact statement What is already known on this subject? A negative correlation between primary tumour SUVmax derived from positron emission tomography (PET/CT) and ADCmin derived from diffusion weighted magnetic resonance imaging (DW-MRI) in various cancer types and cervical cancer has been demonstrated. However, the prognostic value of primary tumour SUVmax and ADCmean in cervical cancer patients treated with definitive chemoradiotherapy is not well studied yet. What the results of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0144-3615 1364-6893 |
| Relation: | http://dx.doi.org/10.1080/01443615.2018.1492528; https://doaj.org/toc/0144-3615; https://doaj.org/toc/1364-6893; https://doaj.org/article/f1c7413ae1254743a8d0907fe554583a |
| DOI: | 10.1080/01443615.2018.1492528 |
| الاتاحة: | https://doi.org/10.1080/01443615.2018.1492528 https://doaj.org/article/f1c7413ae1254743a8d0907fe554583a |
| رقم الانضمام: | edsbas.D39AD8CB |
| قاعدة البيانات: | BASE |
| تدمد: | 01443615 13646893 |
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| DOI: | 10.1080/01443615.2018.1492528 |