Academic Journal
Thy1c Cytology Is a Reliable Method of Excluding Thyroid Cancer in Dominant Cystic Nodules
| العنوان: | Thy1c Cytology Is a Reliable Method of Excluding Thyroid Cancer in Dominant Cystic Nodules |
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| المؤلفون: | Regan, A., Boyd, A., Patel, N., Stechman, M. J., Scott‐Coombes, D. |
| المصدر: | Cytopathology ; ISSN 0956-5507 1365-2303 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2025 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Traditional teaching dictated that patients with recurrent thyroid cysts undergo excision owing to a 12% risk malignancy. Ultrasound evaluation now determines management of these patients augmented by fine needle biopsy. In UK, a non‐diagnostic category for thyroid cysts (Thy1c) exists, whereas the Bethesda system combines ‘non‐diagnostic—cyst fluid only’ into Category I along with paucicellular and acellular results. The aim was to assess the ability of Thy1c cytology to exclude malignancy. Methods We undertook a retrospective study of patients undergoing thyroidectomy with Thy1c cytology from analysis of the Unit database. Additionally, we made a retrospective search in our pathology database for reports combining ‘papillary thyroid carcinoma’ with ‘cyst’ or ‘cystic’ and compared histology with cytology. Results Between 2003 and 2023 115 patients (97 women, median age 44y, range 16–72) underwent thyroidectomy following Thy1c cytology. Indications for surgery included recurrent cyst (90%); compressive symptoms (9%) and one thyrotoxicosis. In no patient was the primary diagnosis malignant; multinodular goitre was commonest (87.76%); benign cyst (19.16%); follicular adenoma (5.4%) and coincidental pT1a classical papillary thyroid carcinoma (PTC) (4.3%). In the retrospective audit, 61 pathology reports contained ‘PTC’ and ‘cyst’/‘cystic’. The cystic element was in primary tumour (31.51%); nodal metastasis (17.28%) and adjacent benign disease (13.21%). Only 5 (8%) patients had Thy1c cytology; 4 had pT1a tumours and one a benign cyst and a 19 mm PTC. Conclusion Thy1c category reliably excludes significant malignancy. For patients with symptomatic cysts, ultrasound assessment and Thy1c cytology can guide the clinician to treat with either ablation or resection without the fear of mistreating a thyroid cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/cyt.13471 |
| الاتاحة: | https://doi.org/10.1111/cyt.13471 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cyt.13471 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.D382D2F1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cyt.13471 |
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