Academic Journal
Brain metabolism changes in middle‐aged asymptomatic APOE‐ε4 carriers. The PESA Study
| العنوان: | Brain metabolism changes in middle‐aged asymptomatic APOE‐ε4 carriers. The PESA Study |
|---|---|
| المؤلفون: | Tristão‐Pereira, Catarina, Toribio‐Fernández, Raquel, Sanchez‐Gonzalez, Javier, Gispert, Juan Domingo, Ibañez, Borja, Cortes‐Canteli, Marta, Fuster, Valentin |
| المصدر: | Alzheimer's & Dementia ; volume 18, issue S6 ; ISSN 1552-5260 1552-5279 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Apolipoprotein E ( APOE ) is the major genetic risk factor for late‐onset Alzheimer’s disease (AD) and is implicated in cardiovascular disease. The APOE ‐ε4 allele is associated with brain hypometabolism in AD, mild cognitive impairment (MCI) ( Mosconi et al. Neurology 2004 ) and in cognitively unimpaired middle‐aged individuals ( Reiman et al. NEJM 1996 ). Greater longitudinal decreases in brain metabolism were reported in APOE ‐ε4 carriers with MCI ( Paranjpe et al. Neuroimage Clin 2019 ), but studies on brain metabolism longitudinal changes in unimpaired middle‐aged APOE ‐ε4 carriers are scarce and with relatively small sample sizes ( Reiman et al. PNAS 2001 ). The Progression of Early Subclinical Atherosclerosis (PESA) study is a longitudinal study following >4000 asymptomatic middle‐aged subjects deeply screened for cardiovascular risk factors (CVRFs) ( Fernandez‐Ortiz et al. AHJ 2013 ). Individuals with the highest burden of atherosclerosis underwent FDG‐PET at baseline and CVRFs were associated with hypometabolism in AD regions (Cortés‐Canteli & Gispert et al. JACC 2021). Those individuals underwent a 6‐year follow‐up FDG‐PET. Here, we investigate the effect of APOE genotype on brain metabolism progression in middle‐aged asymptomatic individuals. Method 365 cognitively unimpaired adults (mean age 50 years old) were genotyped for APOE and underwent two FDG‐PET studies ( Table ). Baseline and follow‐up images were spatially normalized to a group template in the MNI space. FDG‐uptake was normalized to the pons and images were subtracted, yielding a measure of brain metabolic change. An ANOVA model was carried out to compare brain metabolism change between APOE‐ Result At the global level, we observed significantly greater decreases in FDG uptake in ε4 carriers compared to the reference ε3/ε3 genotype (p=0.024). Voxelwise analysis showed greater decreases between ε4 carriers and non‐ε4 carriers in the precuneus, supramarginal gyrus, hippocampus and anterior cingulate gyrus ( Figure ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/alz.067161 |
| الاتاحة: | http://dx.doi.org/10.1002/alz.067161 https://onlinelibrary.wiley.com/doi/pdf/10.1002/alz.067161 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/alz.067161 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.D35F9993 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/alz.067161 |
|---|