Academic Journal
Prolonged progression-free survival achieved by gemcitabine, cisplatin, and albumin-bound paclitaxel for the treatment of advanced biliary tract cancers
| العنوان: | Prolonged progression-free survival achieved by gemcitabine, cisplatin, and albumin-bound paclitaxel for the treatment of advanced biliary tract cancers |
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| المؤلفون: | Jin Ho Choi, Hwanhee Park, Joo Kyung Park, Jong Kyun Lee, Kyu Taek Lee, Kwang Hyuck Lee |
| المصدر: | Therapeutic Advances in Medical Oncology, Vol 16 (2024) |
| بيانات النشر: | SAGE Publishing |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background: A regimen of gemcitabine, cisplatin, and nab-paclitaxel (GPA) has shown promising results in patients with advanced biliary tract cancer (aBTC). Objectives: This study aimed to evaluate the benefit of GPA compared to a regimen of gemcitabine plus cisplatin (GP) in patients with aBTC. Design: Retrospective study. Methods: Patients with aBTC who received first-line chemotherapy with GPA or GP regimen at the Samsung Medical Center between July 2020 and June 2022 were included. The primary endpoint was progression-free survival (PFS). Results: In all, 37 patients were treated with GPA and 43 patients with GP. The GPA group showed significantly longer median PFS [12.0 months (95% CI, 7.2–16.8)] compared to the GP group [5.5 months (95% CI, 3.7–7.4; p = 0.007)]. The median overall survival (OS) was also longer in the GPA group [18.7 months (95% CI, 13.7–23.7)] than in the GP group [10.7 months (95% CI, 1.5–19.9); p = 0.021]. First-line chemotherapy with GPA was associated with longer PFS, while metastatic disease at initial diagnosis and post-treatment increase in CA 19-9 level were associated with worse PFS. Conclusion: The GPA regimen improved the PFS of patients with aBTC compared to the GP regimen but showed no significant benefit in terms of OS after adjusting for confounding variables. Further large-scale studies are required to establish optimal indications for GPA. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1758-8359 |
| Relation: | https://doi.org/10.1177/17588359231225045; https://doaj.org/toc/1758-8359; https://doaj.org/article/b893d6a07f724bd88b7ecd534a0b554a |
| DOI: | 10.1177/17588359231225045 |
| الاتاحة: | https://doi.org/10.1177/17588359231225045 https://doaj.org/article/b893d6a07f724bd88b7ecd534a0b554a |
| رقم الانضمام: | edsbas.D34CA77A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17588359 |
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| DOI: | 10.1177/17588359231225045 |