Academic Journal
Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation
| العنوان: | Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation |
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| المؤلفون: | Vijay, Rahul, Guthmiller, Jenna J., Sturtz, Alexandria J., Crooks, Sequoia, Johnson, Jordan T., Li, Lei, Lan, Linda Yu-Ling, Pope, Rosemary L., Chen, Yani, Rogers, Kai J., Dutta, Nirmal, Toombs, Jason E., Wilson, Mary E., Wilson, Patrick C., Maury, Wendy, Brekken, Rolf A., Butler, Noah S. |
| المساهمون: | National Cancer Institute, National Center for Research Resources, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, US Department of Veterans Affairs |
| المصدر: | Journal of Experimental Medicine ; volume 218, issue 6 ; ISSN 0022-1007 1540-9538 |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2021 |
| الوصف: | Antimalarial antibody responses are essential for mediating the clearance of Plasmodium parasite–infected RBCs from infected hosts. However, the rapid appearance of large numbers of plasmablasts in Plasmodium-infected hosts can suppress the development and function of durable humoral immunity. Here, we identify that the formation of plasmablast populations in Plasmodium-infected mice is mechanistically linked to both hemolysis-induced exposure of phosphatidylserine on damaged RBCs and inflammatory cues. We also show that virus and Trypanosoma infections known to trigger hemolytic anemia and high-grade inflammation also induce exuberant plasmablast responses. The induction of hemolysis or administration of RBC membrane ghosts increases plasmablast differentiation. The phosphatidylserine receptor Axl is critical for optimal plasmablast formation, and blocking phosphatidylserine limits plasmablast expansions and reduces Plasmodium parasite burden in vivo. Our findings support that strategies aimed at modulating polyclonal B cell activation and phosphatidylserine exposure may improve immune responses against Plasmodium parasites and potentially other infectious diseases that are associated with anemia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1084/jem.20202359 |
| DOI: | 10.1084/jem.20202359/1832962/jem_20202359.pdf |
| الاتاحة: | http://dx.doi.org/10.1084/jem.20202359 https://rupress.org/jem/article-pdf/doi/10.1084/jem.20202359/1832962/jem_20202359.pdf |
| Rights: | http://www.rupress.org/terms/ ; https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| رقم الانضمام: | edsbas.D3113DB2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20202359 |
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