Academic Journal
Evidence for treatment with estradiol for women with SARS-CoV-2 infection
| العنوان: | Evidence for treatment with estradiol for women with SARS-CoV-2 infection |
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| المؤلفون: | Seeland, Ute, Coluzzi, Flaminia, Simmaco, Maurizio, Mura, Cameron, Bourne, Philip E., Heiland, Max, Preissner, Robert, Preissner, Saskia |
| المصدر: | http://lobid.org/resources/99370672989506441#!, 18(1):369. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | COVID-19, Male [MeSH], Sex Characteristics [MeSH], COVID-19/epidemiology [MeSH], SARS-CoV-2 [MeSH], Research Article, SARS-CoV-2, Women, Adolescent [MeSH], Female [MeSH], Adult [MeSH], ACE2, Humans [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Estradiol, Sex, COVID-19/prevention, Pneumonia, Viral/drug therapy [MeSH], Hormone treatment, Young Adult [MeSH], Peptidyl-Dipeptidase A/therapeutic use [MeSH], Viral/epidemiology [MeSH], Estradiol/therapeutic use [MeSH] |
| الوصف: | Background!#!Given that an individual's age and gender are strongly predictive of coronavirus disease 2019 (COVID-19) outcomes, do such factors imply anything about preferable therapeutic options?!##!Methods!#!An analysis of electronic health records for a large (68,466-case), international COVID-19 cohort, in 5-year age strata, revealed age-dependent sex differences. In particular, we surveyed the effects of systemic hormone administration in women. The primary outcome for estradiol therapy was death. Odds ratios (ORs) and Kaplan-Meier survival curves were analyzed for 37,086 COVID-19 women in two age groups: pre- (15-49 years) and peri-/post-menopausal (> 50 years).!##!Results!#!The incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is higher in women than men (by about + 15%) and, in contrast, the fatality rate is higher in men (about + 50%). Interestingly, the relationships between these quantities are linked to age: pre-adolescent girls and boys had the same risk of infection and fatality rate, while adult premenopausal women had a significantly higher risk of infection than men in the same 5-year age stratum (about 16,000 vs. 12,000 cases). This ratio changed again in peri- and postmenopausal women, with infection susceptibility converging with men. While fatality rates increased continuously with age for both sexes, at 50 years, there was a steeper increase for men. Thus far, these types of intricacies have been largely neglected. Because the hormone 17ß-estradiol influences expression of the human angiotensin-converting enzyme 2 (ACE2) protein, which plays a role in SARS-CoV-2 cellular entry, propensity score matching was performed for the women's sub-cohort, comparing users vs. non-users of estradiol. This retrospective study of hormone therapy in female COVID-19 patients shows that the fatality risk for women > 50 years receiving estradiol therapy (user group) is reduced by more than 50%; the OR was 0.33, 95% CI [0.18, 0.62] and the hazard ratio (HR) was 0.29, 95% ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6464237; https://doi.org/10.1186/s12916-020-01851-z; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685778/ |
| DOI: | 10.1186/s12916-020-01851-z |
| الاتاحة: | https://repository.publisso.de/resource/frl:6464237 https://doi.org/10.1186/s12916-020-01851-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685778/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.D2E9518 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12916-020-01851-z |
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