Academic Journal
Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies
| العنوان: | Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies |
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| المؤلفون: | Köhler, C A, Freitas, T H, Maes, M, de Andrade, N Q, Liu, C S, Fernandes, B S, Stubbs, B, Solmi, M, Veronese, N, Herrmann, N, Raison, C L, Miller, B J, Lanctôt, K L, Carvalho, A F |
| المصدر: | Köhler , C A , Freitas , T H , Maes , M , de Andrade , N Q , Liu , C S , Fernandes , B S , Stubbs , B , Solmi , M , Veronese , N , Herrmann , N , Raison , C L , Miller , B J , Lanctôt , K L & Carvalho , A F 2017 , ' Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies ' , Acta Psychiatrica Scandinavica . https://doi.org/10.1111/acps.12698 |
| سنة النشر: | 2017 |
| المجموعة: | King's College, London: Research Portal |
| الوصف: | OBJECTIVE: To conduct a systematic review and meta-analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs). METHOD: The PubMed/MEDLINE, EMBASE, and PsycINFO databases were searched up until May 30, 2016. Effect sizes were estimated with random-effects models. RESULT: Eighty-two studies comprising 3212 participants with MDD and 2798 HCs met inclusion criteria. Peripheral levels of interleukin-6 (IL-6), tumor necrosis factor (TNF)-alpha, IL-10, the soluble IL-2 receptor, C-C chemokine ligand 2, IL-13, IL-18, IL-12, the IL-1 receptor antagonist, and the soluble TNF receptor 2 were elevated in patients with MDD compared to HCs, whereas interferon-gamma levels were lower in MDD (Hedge's g = -0.477, P = 0.043). Levels of IL-1β, IL-2, IL-4, IL-8, the soluble IL-6 receptor (sIL-6R), IL-5, CCL-3, IL-17, and transforming growth factor-beta 1 were not significantly altered in individuals with MDD compared to HCs. Heterogeneity was large (I(2) : 51.6-97.7%), and sources of heterogeneity were explored (e.g., age, smoking status, and body mass index). CONCLUSION: Our results further characterize a cytokine/chemokine profile associated with MDD. Future studies are warranted to further elucidate sources of heterogeneity, as well as biosignature cytokines secreted by other immune cells. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1111/acps.12698 |
| الاتاحة: | https://kclpure.kcl.ac.uk/portal/en/publications/1854664c-43c8-4316-9a16-122e36473251 https://doi.org/10.1111/acps.12698 https://kclpure.kcl.ac.uk/ws/files/67385978/Peripheral_cytokine_and_chemokine_KOHLER_Accepted29December2016_GREEN_AAM.pdf https://kclpure.kcl.ac.uk/ws/files/67385980/Peripheral_cyotokine_and_chemokine_KOHLER_Supp_materials.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D2C68DD5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/acps.12698 |
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