Academic Journal
Pertussis Vaccines Scarcely Provide Protection against Bordetella parapertussis Infection in Children—A Systematic Review and Meta-Analysis
| العنوان: | Pertussis Vaccines Scarcely Provide Protection against Bordetella parapertussis Infection in Children—A Systematic Review and Meta-Analysis |
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| المؤلفون: | Arun Thachappully Remesh, Kalichamy Alagarasu, Santoshkumar Jadhav, Meera Prabhakar, Rajlakshmi Viswanathan |
| المصدر: | Vaccines, Vol 12, Iss 3, p 253 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | pertussis, parapertussis, whole cellular pertussis vaccine, acellular pertussis vaccine, protection, effectiveness, Medicine |
| الوصف: | Background: Pertussis, or whooping cough, is a global public health concern. Pertussis vaccines have demonstrated good protection against Bordetella pertussis infections, but their effectiveness against Bordetella parapertussis remains debated due to conflicting study outcomes. Methods: A systematic review and meta-analysis were conducted to assess the effectiveness of pertussis vaccines in protecting children against B. parapertussis infection. A comprehensive search of PubMed, Web of Science, and Scopus databases was conducted, and randomized controlled trials (RCTs) and observational studies that met inclusion criteria were included in the analysis. Results: The meta-analysis, involving 46,533 participants, revealed no significant protective effect of pertussis vaccination against B. parapertussis infection (risk ratio: 1.10, 95% confidence interval: 0.83 to 1.44). Subgroup analyses by vaccine type and study design revealed no significant protection. The dearth of recent data and a limited pool of eligible studies, particularly RCTs, underscore a critical gap that warrants future research in the domain. Conclusions: These findings offer crucial insights into the lack of effectiveness of pertussis vaccines against B. parapertussis . Given the rising incidence of cases and outbreaks, coupled with the lack of cross-protection by the existing vaccines, there is an urgent need to develop vaccines that include specific antigens to protect against B. parapertussis . |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2076-393X |
| Relation: | https://www.mdpi.com/2076-393X/12/3/253; https://doaj.org/toc/2076-393X; https://doaj.org/article/0219fa68013f4f7993d2bfc3abe952cd |
| DOI: | 10.3390/vaccines12030253 |
| الاتاحة: | https://doi.org/10.3390/vaccines12030253 https://doaj.org/article/0219fa68013f4f7993d2bfc3abe952cd |
| رقم الانضمام: | edsbas.D2C0FDD0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2076393X |
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| DOI: | 10.3390/vaccines12030253 |