Academic Journal
Fulvestrant (FaslodexTM) in advanced breast cancer: clinical experience from a Belgian cooperative study
| العنوان: | Fulvestrant (FaslodexTM) in advanced breast cancer: clinical experience from a Belgian cooperative study |
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| المؤلفون: | Neven, P., Paridaens, R., Pelgrims, G., Martens, M., Bols, A., Goeminne, JC., Vindevoghel, A., Demol, J., Stragier, B., De Greve, J., Fontaine, C., Van Den Weyngaert, D., Becquart, D., Borms, M., Cocquyt, V., Van Den Broecke, R., Selleslags, J., Awada, A., Dirix, L., Van Dam, P., Azerad, Marie-Agnès, Vandenhoven, G., Christiaens, MR. |
| المصدر: | Breast Cancer Research and Treatment, 109, 59-65 (2008-05) |
| بيانات النشر: | Kluwer Academic Publishers |
| سنة النشر: | 2008 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Advanced or metastatic breast cancer, Compassionate use, Endocrine, Fulvestrant, Postmenopausal, Human health sciences, Hematology, Sciences de la santé humaine, Hématologie |
| الوصف: | peer reviewed ; Fulvestrant (FaslodexTM) is a new estrogen receptor (ER) antagonist with no agonist effects that is licensed for the treatment of postmenopausal women with hormone-sensitive advanced breast cancer (ABC) who have progressed/recurred on prior antiestrogen therapy. The FaslodexTM Compassionate Use Program (CUP) provides expanded access to fulvestrant in countries where it is not yet available for patients who are not eligible to enter clinical trials. This analysis pools data from 402 patients who received fulvestrant as part of the CUP in Belgium, predominantly as 3rd- to 5th-line endocrine therapy for ABC. Two patients experienced partial responses and 118 experienced stable disease lasting ‡6 months, resulting in an overall clinical benefit rate of 29.9%. Fulvestrant was active in patients with multiple sites of metastases, visceral metastases, human epidermal growth factor receptor 2- positive disease and after heavy endocrine pre-treatment. Fulvestrant was well tolerated, with only six patients (1.5%) discontinuing treatment following adverse events. These data support the findings of previous CUP analyses and Phase II and III trials, suggesting that fulvestrant is a valuable addition to the treatment sequence for postmenopausal women with ABC who have progressed/recurred on prior endocrine therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0167-6806 1573-7217 |
| Relation: | urn:issn:0167-6806; urn:issn:1573-7217; https://orbi.uliege.be/handle/2268/229475; info:hdl:2268/229475; https://orbi.uliege.be/bitstream/2268/229475/1/Fulvestrant_Faslodex_in_advanced_breast_cancer_Cli.pdf; info:pmid:17592772 |
| DOI: | 10.1007/s10549-007-9628-2 |
| الاتاحة: | https://orbi.uliege.be/handle/2268/229475 https://orbi.uliege.be/bitstream/2268/229475/1/Fulvestrant_Faslodex_in_advanced_breast_cancer_Cli.pdf https://doi.org/10.1007/s10549-007-9628-2 |
| Rights: | open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D2AFA1F2 |
| قاعدة البيانات: | BASE |
| تدمد: | 01676806 15737217 |
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| DOI: | 10.1007/s10549-007-9628-2 |