Academic Journal
Prevalence and early‐life risk factors of school‐age allergic multimorbidity: The EuroPrevall‐iFAAM birth cohort
| العنوان: | Prevalence and early‐life risk factors of school‐age allergic multimorbidity: The EuroPrevall‐iFAAM birth cohort |
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| المؤلفون: | Sigurdardottir, Sigurveig T., Jonasson, Kristjan, Clausen, Michael, Lilja Bjornsdottir, Kristin, Sigurdardottir, Sigridur Erla, Roberts, Graham, Grimshaw, Kate, Papadopoulos, Nikolaos G., Xepapadaki, Paraskevi, Fiandor, Ana, Quirce, Santiago, Sprikkelman, Aline B., Hulshof, Lies, Kowalski, Marek L., Kurowski, Marcin, Dubakiene, Ruta, Rudzeviciene, Odilija, Bellach, Johanna, Yürek, Songül, Reich, Andreas, Erhard, Sina Maria, Couch, Philip, Rivas, Montserrat Fernandez, van Ree, Ronald, Mills, Clare, Grabenhenrich, Linus, Beyer, Kirsten, Keil, Thomas |
| المساهمون: | FP7 Ideas: European Research Council, Sixth Framework Programme |
| المصدر: | Allergy ; volume 76, issue 9, page 2855-2865 ; ISSN 0105-4538 1398-9995 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Coexistence of childhood asthma, eczema and allergic rhinitis is higher than can be expected by chance, suggesting a common mechanism. Data on allergic multimorbidity from a pan‐European, population‐based birth cohort study have been lacking. This study compares the prevalence and early‐life risk factors of these diseases in European primary school children. Methods In the prospective multicentre observational EuroPrevall‐iFAAM birth cohort study, we used standardized questionnaires on sociodemographics, medical history, parental allergies and lifestyle, and environmental exposures at birth, 12 and 24 months. At primary school age, parents answered ISAAC‐based questions on current asthma, rhinitis and eczema. Allergic multimorbidity was defined as the coexistence of at least two of these. Results From 10,563 children recruited at birth in 8 study centres, we included data from 5,572 children (mean age 8.2 years; 51.8% boys). Prevalence estimates were as follows: asthma, 8.1%; allergic rhinitis, 13.3%; and eczema, 12.0%. Allergic multimorbidity was seen in 7.0% of the whole cohort, ranging from 1.2% (Athens, Greece) to 10.9% (Madrid, Spain). Risk factors for allergic multimorbidity, identified with AICc, included family‐allergy‐score, odds ratio (OR) 1.50 (95% CI 1.32–1.70) per standard deviation; early‐life allergy symptoms, OR 2.72 (2.34–3.16) for each symptom; and caesarean birth, OR 1.35 (1.04–1.76). Female gender, OR 0.72 (0.58–0.90); older siblings, OR 0.79 (0.63–0.99); and day care, OR 0.81 (0.63–1.06) were protective factors. Conclusion Allergic multimorbidity should be regarded as an important chronic childhood disease in Europe. Some of the associated early‐life factors are modifiable and may be considered for prevention strategies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/all.14857 |
| الاتاحة: | http://dx.doi.org/10.1111/all.14857 https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.14857 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/all.14857 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.D28611FB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/all.14857 |
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