Academic Journal
Post-tuberculosis respiratory impairment in Gambian children and adolescents: A cross-sectional analysis.
| العنوان: | Post-tuberculosis respiratory impairment in Gambian children and adolescents: A cross-sectional analysis. |
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| المؤلفون: | Nkereuwem, Esin, Agbla, Schadrac, Njai, Bintou, Edem, Victory Fabian, Jatta, Muhammed Lamin, Owolabi, Olumuyiwa, Masterton, Uma, Jah, Fatoumatta, Danso, Madikoi, Fofana, Aunty Nyima, Samateh, Wandifa, Darboe, Muhammed Lamin, Owusu, Sheila Ageiwaa, Bush, Andrew, Kampmann, Beate, Togun, Toyin |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| الوصف: | BACKGROUND: Although post-tuberculosis lung disease (PTLD) is a known consequence of pulmonary tuberculosis (pTB), few studies have reported the prevalence and spectrum of PTLD in children and adolescents. METHODS: Children and adolescent (≤19 years) survivors of pTB in the Western Regions of The Gambia underwent a respiratory symptom screening, chest X-ray (CXR) and spirometry at TB treatment completion. Variables associated with lung function impairment were identified through logistic regression models. RESULTS: Between March 2022 and July 2023, 79 participants were recruited. The median age was 15.6 years (IQR: 11.8, 17.9); the majority, 53/79 (67.1%), were treated for bacteriologically confirmed pTB, and 8/79 (10.1%) were children and adolescents living with HIV. At pTB treatment completion, 28/79 (35.4%) reported respiratory symptoms, 37/78 (47.4%) had radiological sequelae, and 45/79 (57.0%) had abnormal spirometry. The most common respiratory sequelae were cough (21/79, 26.6%), fibrosis on CXR (22/78, 28.2%), and restrictive spirometry (41/79, 51.9%). Age at TB diagnosis over ten years, undernutrition and fibrosis on CXR at treatment completion were significantly associated with abnormal spirometry (p = .050, .004, and .038, respectively). CONCLUSION: Chronic respiratory symptoms, abnormal CXR, and impaired lung function are common and under-reported consequences of pTB in children and adolescents. Post-TB evaluation and monitoring may be necessary to improve patient outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://researchonline.lshtm.ac.uk/id/eprint/4672479/1/Nkereuwem_etal_2024_Post%E2%80%90tuberculosis-respiratory-impairment.pdf; Nkereuwem, Esin ; Agbla, Schadrac ; Njai, Bintou; Edem, Victory Fabian; Jatta, Muhammed Lamin; Owolabi, Olumuyiwa; Masterton, Uma; Jah, Fatoumatta; Danso, Madikoi; Fofana, Aunty Nyima; +6 more. Samateh, Wandifa; Darboe, Muhammed Lamin; Owusu, Sheila Ageiwaa ; Bush, Andrew; Kampmann, Beate ; Togun, Toyin ; (2024) Post-tuberculosis respiratory impairment in Gambian children and adolescents: A cross-sectional analysis. Pediatric pulmonology, 59 (7). pp. 1912-1921. ISSN 8755-6863 DOI: https://doi.org/10.1002/ppul.27009 |
| DOI: | 10.1002/ppul.27009 |
| الاتاحة: | https://researchonline.lshtm.ac.uk/id/eprint/4672479/ https://researchonline.lshtm.ac.uk/id/eprint/4672479/1/Nkereuwem_etal_2024_Post%E2%80%90tuberculosis-respiratory-impairment.pdf https://doi.org/10.1002/ppul.27009 |
| Rights: | cc_by_4 |
| رقم الانضمام: | edsbas.D250FD80 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ppul.27009 |
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